Actively Recruiting
The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium
Led by Medical University of Vienna · Updated on 2025-04-30
1332
Participants Needed
2
Research Sites
278 weeks
Total Duration
On this page
Sponsors
M
Medical University of Vienna
Lead Sponsor
M
Medical University Innsbruck
Collaborating Sponsor
AI-Summary
What this Trial Is About
Patients over the age of 65 years are at increased risk for developing delirium after noncardiac surgeries, resulting in increased morbidity and mortality. The prevention of postoperative delirium has been classified as a public health priority. However, so far data regarding possible intraoperative interventions to reduce the incidence of postoperative delirium is very scarce. Due to the more rapid wash-in and wash-out times of desflurane as compared to sevoflurane or propofol it seems reasonable that desflurane might be beneficial for the prevention of postoperative delirium. Therefore, we evaluate the effect of maintenance of anesthesia using desflurane, sevoflurane or propofol on postoperative delirium in elderly patients undergoing moderate- to high-risk major noncardiac surgery.
CONDITIONS
Official Title
The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provide written informed consent
- ≥65 years of age
- Scheduled for elective major noncardiac surgery with estimated time of surgery ≥ 2 hours
You will not qualify if you...
- Patients undergoing emergency surgery
- BMI > 45 kg/m^2
- History of diagnosed dementia
- Language, vision, or hearing impairments that may compromise cognitive assessments
- History of malignant hyperthermia
- History of structural muscle disease
- History of organ transplantation (kidney, liver, lung, heart)
- Patients undergoing hyperthermic intraperitoneal chemotherapy
- ICU patients undergoing surgery
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Trial Site Locations
Total: 2 locations
1
Medical University of Innsbruck
Innsbruck, Austria, 6020
Actively Recruiting
2
Medical University of Vienna
Vienna, Austria, 1090
Actively Recruiting
Research Team
A
Alexander Taschner, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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