Actively Recruiting
Effect of Dexamethasone on Post-spinal Hypotension in Geriatric Patients Undergoing Orthopaedic Surgery at Tertiary Care Hospital Karachi
Led by Shaheed Mohtarma Benazir Bhutto Institue of Trauma · Updated on 2025-02-11
170
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This trial investigates whether intravenous dexamethasone can prevent low blood pressure after spinal anesthesia in older adults having orthopedic surgeries on their lower limbs. Researchers aim to see if giving dexamethasone before surgery reduces post-spinal hypotension compared to a placebo. The study focuses on geriatric patients aged 65 to 85 years undergoing these procedures. Participants are randomly assigned to one of two groups. One group receives an 8 mg dose of intravenous dexamethasone about 20 minutes before spinal anesthesia. The other group receives a placebo intravenously at the same time before the spinal anesthesia. This is a phase 4, single-blind, randomized study conducted at a tertiary care hospital. During the trial, participants' blood pressure is monitored from enrollment until 30 minutes after spinal anesthesia to assess the occurrence of hypotension. Researchers will compare the effects of dexamethasone versus placebo on this outcome. The total participation duration includes preoperative administration and monitoring immediately after spinal anesthesia. Safety and other assessments are performed as part of routine care during this period.
CONDITIONS
Brief Title
Effect of Dexamethasone on Post-spinal Hypotension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient undergoing orthopedic surgery in spinal anesthesia
- ASA physical status classification of 2 or less
- Age between 65 and 85 years
You will not qualify if you...
- History of cardiac arrhythmias
- History of acute coronary syndrome
- History of polytrauma
- Contraindications to spinal anesthesia such as coagulopathy, thrombocytopenia, or allergy to local anesthetic agents
- Current use of steroids or serotonin-related medications such as selective serotonin reuptake inhibitors (SSRIs)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From preoperative dosing to 30 minutes after spinal anesthesia
Participants receive intravenous dexamethasone or placebo 20 minutes before spinal anesthesia as part of orthopedic surgery.
1 treatment visit (in-person)
Trial Site Locations
Total: 1 location
1
Shaheed Mohtarma Benazir Bhutto Institute of Trauma
Karachi, Sindh, Pakistan
Actively Recruiting
Research Team
S
Sidra Javed, MBBS, FCPS, Pain fellow
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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