Actively Recruiting
Effect of Dexmedetomidine and Esketamine on Catheter-related Bladder Discomfort
Led by Peking University First Hospital · Updated on 2025-07-31
1740
Participants Needed
2
Research Sites
151 weeks
Total Duration
On this page
Sponsors
P
Peking University First Hospital
Lead Sponsor
P
Peking University Shenzhen Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Catheter-related bladder discomfort (CRBD) is common in patients awaking from general anesthesia with an urinary catheter. We suppose that that use of dexmedetomidine and/or esketamine during anesthesia may reduce the occurrence of CRBD. This 2x2 factorial randomized trial is designed to explore the effects of esketamine, dexmedetomidine, and their combination on the occurrence CRBD in patients undergoing transurethral urological surgery.
CONDITIONS
Official Title
Effect of Dexmedetomidine and Esketamine on Catheter-related Bladder Discomfort
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or above
- Scheduled to undergo transurethral bladder or prostate surgery under general anesthesia
- Required postoperative retention of a three-chamber urinary catheter
You will not qualify if you...
- Indwelling urinary catheters or chronic analgesic therapy for 1 month or more before surgery
- Uncontrolled hypertension before surgery (resting systolic >180 mmHg or diastolic >110 mmHg)
- Severe bradycardia (heart rate ≤50 beats per minute), sick sinus syndrome, or atrioventricular block of degree II or above without pacemaker
- History of myocardial infarction, severe heart insufficiency (New York Heart Association class ≥3), or tachyarrhythmia within a year
- Preoperative history of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or intracranial hypertension
- Preoperative history of hyperthyroidism and pheochromocytoma
- Inability to communicate due to coma, severe dementia, or language barrier before surgery
- Severe liver dysfunction (Child-Pugh grade C), severe renal dysfunction (receiving dialysis before surgery), or American Society of Anesthesiologists classification ≥IV
- Scheduled admission to the intensive care unit with endotracheal intubation after surgery
- Other conditions considered unsuitable for study participation
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
2
Peking University Shenzhen Hospital
Shenzhen, Guangdong, China, 518036
Actively Recruiting
Research Team
R
Rui Zhang, MD
CONTACT
L
Li Huaijin, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
4
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