Actively Recruiting
Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane
Led by Baylor College of Medicine · Updated on 2025-09-22
180
Participants Needed
1
Research Sites
410 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this protocol is to determine the effect of two clinically applicable Dexmedetomidine dosages (0.5mcg/kg and 1mcg/kg) on the minimum alveolar concentration (MAC) of Sevoflurane in children between the age ranges of: 1-6 months; 6-12 months of age and 12 months-36 months years of age.
CONDITIONS
Official Title
Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 1 month to 3 years presenting for surgery
You will not qualify if you...
- Interstitial lung disease, chest wall disease, or bronchospastic disease with flare-ups in the past 2 weeks
- History of difficult intubation or ventilation
- Airway malformation
- Congenital heart disease
- Cardiac arrhythmias
- Central nervous system disease including developmental delay, cerebral palsy, or seizure disorder
- History of or family history of malignant hyperthermia
- Electrolyte disorders
- Gastrointestinal disease
- Hepatic dysfunction
- Renal dysfunction
- Metabolic diseases such as diabetes
- Obesity defined as body mass index greater than the 95th percentile for age
- Preterm infant (less than 37 weeks gestational age)
- Use of medications that may affect MAC, including anticonvulsants, opioids, benzodiazepines, antibiotics, antihistamines, or drugs that induce hepatic enzymes
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Texas Children's Hospital
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
M
Margaret Owens-Stuberfield
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
9
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