Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT05195034

Effect of Dexmedetomidine on Postoperative Delirium After Awake Craniotomies

Led by Beijing Tiantan Hospital · Updated on 2025-02-13

210

Participants Needed

1

Research Sites

195 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Postoperative delirium (POD) is a common complication, and the incidence of POD ranges from 10% to 60%. Previous studies suggested that frontal approach and tumor located at the temporal lobe were independent risk factors for POD after supratentorial tumor resections. Therefore, patients undergoing awake craniotomies are high-risk populations for POD. A lot of trials show that dexmedetomidine might help to reduce the incidence of delirium in patients undergoing non-cardiac surgery. However, the impact of dexmedetomidine (DEX) on POD for patients undergoing awake craniotomies remains unclear. The purpose of this study was to investigate the effect of DEX on POD in patients undergoing awake craniotomies.

CONDITIONS

Official Title

Effect of Dexmedetomidine on Postoperative Delirium After Awake Craniotomies

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients undergoing selective awake craniotomies.
  • Age 18 years or older.
  • Able to provide written informed consent.
Not Eligible

You will not qualify if you...

  • Moderate or severe cognitive impairment before surgery (MoCA less than 18).
  • Use of psychotropic medication within the past year.
  • Body mass index less than 18 or greater than 30 Kg/m2.
  • Pregnant or breastfeeding women.
  • History of traumatic brain injury or previous neurosurgery.
  • Severe slow heart rate (less than 40 beats per minute), sick sinus syndrome, or advanced heart block.
  • Severe liver or kidney dysfunction.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Beijing Tian Tan Hospital, Capital Medical University

Beijing, Beijing Municipality, China, 100160

Actively Recruiting

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Research Team

Y

Yuming Peng, MD,Ph.D

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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Effect of Dexmedetomidine on Postoperative Delirium After Awake Craniotomies | DecenTrialz