Study of Different Deproteinizing Agents to Improve the Success of Fissure Sealants on Permanent Teeth in Children Ages 6 to 9

What this Trial Is About

Researchers are investigating how different deproteinization agents affect the success of non-invasive fissure sealant applications on permanent teeth. This study focuses on preventing or stopping early enamel caries in high-risk tooth surfaces by comparing two agents sodium hypochlorite NaOCl and hypochlorous acid HOCl. The trial aims to provide new clinical evidence on the effectiveness of HOCl, which has shown promising antimicrobial and tissue-tolerated properties in dental care. Participants in this trial receive fissure sealant treatment combined with one of two deproteinization agents applied before acid etching 5.25% sodium hypochlorite, known for its adhesion benefits but with some disadvantages such as irritation risk and bad odor, or hypochlorous acid, a newer, less acidic agent produced by the bodys immune cells with reported biocompatibility and antimicrobial activity. The study randomly assigns children to one of these groups and monitors the clinical success of the sealants over time. Children aged 6 to 9 with newly erupted permanent lower first molars suitable for sealant application are followed up at 6, 12, 24, and 36 months after treatment. Researchers assess sealant retention and edge integrity using established criteria to measure outcomes. The study includes behavior assessments and excludes children with certain dental or systemic conditions. Participation involves regular dental check-ups to evaluate the sealants condition and any changes in the treated teeth.

The Effect of Different Deproteinising Agents on the Clinical Success of Fissure Sealants in Permanent Teeth