Comparison between Silk Sutures and Cyanoacrylate Adhesive in Human Mucosa- A Clinical and Histological Study.
M Suresh Kumar, Sreelakshmi Natta, Gowri Shankar...
https://pubmed.ncbi.nlm.nih.gov/24324311Actively Recruiting
Phase Not Applicable
Age: 18Years - 40Years
All Genders
ID07198282
The Effect of Different Flap Closure Techniques on Postoperative Morbidity: A Randomized Controlled Trial for Impacted Third Molar Surgery
Led by Recep Tayyip Erdogan University · Updated on 2026-01-12
148
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating four different flap closure techniques to reduce common postoperative problems such as pain, swelling, difficulty opening the mouth, and wound healing issues after impacted mandibular third molar (wisdom tooth) extraction. This randomized controlled trial aims to compare the clinical effects and safety of conventional suturing, sutureless technique, surgical drain, and cyanoacrylate tissue adhesive on patient recovery and quality of life. These methods are widely used in oral surgery, and the study seeks to identify which approach best improves patient outcomes. The study includes four treatment groups: one using traditional silk sutures to close the wound edges; another leaving the wound to heal naturally without sutures (sutureless); a third group receiving a sterile plastic drain to remove fluids and reduce swelling; and a fourth where a cyanoacrylate-based medical adhesive is applied for rapid wound closure. All procedures follow standardized protocols performed by experienced surgeons. Participants will be monitored closely with follow-up visits on days 2 and 7 after surgery to assess pain, swelling, mouth opening ability, and wound healing progress. Quality of life is measured using the General Oral Health Assessment Index (GOHAI) on day 7. Safety is carefully tracked, including any infections or complications. The total participation spans the immediate postoperative period with evaluations up to 14 days after surgery to determine the best flap closure method for reducing morbidity.
CONDITIONS
Brief Title
The Effect of Different Flap Closure Techniques on Postoperative Morbidity in Impacted Third Molar Surgery
Who Can Participate
Age: 18Years - 40Years
All Genders
Eligibility Criteria
You may qualify if you...
- Patients aged 18-40 years.
- Patients with no systemic diseases (ASA I).
- Patients with impacted mandibular third molars indicated for extraction, with bone and/or mucosal retention, in similar positions (Pell & Gregory Class 2, Position B; Winter classification vertical or mesioangular).
You will not qualify if you...
- Patients classified as ASA II, III, or IV.
- Known allergy to anesthetic solutions.
- Allergy to acrylate.
- Pregnant or breastfeeding women.
- Individuals with tobacco use ≥10 cigarettes/day.
- Alcohol users.
- Patients using antiplatelet agents.
- Patients using anticoagulants.
- Patients with coagulation disorders.
- Patients with immunosuppressive diseases or receiving immunosuppressive therapy.
- Patients with acute pain or local infection at the surgical site.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Surgery and Immediate Post-operative Care
Duration - Day of surgery
Participants undergo impacted mandibular third molar extraction using one of four flap closure techniques: Conventional Suturing, Sutureless Technique, Surgical Drain, or Cyanoacrylate Tissue Adhesive.
1 visit (in-person)
Post-operative Follow-up
Duration - 14 days after surgery
Participants are monitored for postoperative pain, swelling, trismus, wound healing, and quality of life after surgery.
Visits on Days 1, 2, 3, 7, and 14 (in-person)
Trial Site Locations
Total: 1 location
1
Recep Tayyip Erdoğan University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery
Rize, Rize Province, Turkey (Türkiye)
Actively Recruiting
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Research Team
A
Alperen Kalyoncu, Assistant Professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
4
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Published Research Related To This Trial
Analysing inflammatory responses after mandibular third molar extraction: a comparison of suture-less and multiple suture techniques.
Archana Sen, Vikas Dhupar, Francis Akkara
https://pubmed.ncbi.nlm.nih.gov/39117914The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction.
M Madrazo-Jiménez, Á Rodríguez-Caballero, M-Á Serrera-Figallo...
https://pubmed.ncbi.nlm.nih.gov/27475700Reliability and validity of the Geriatric Oral Health Assessment Index in Turkey.
Safak Ergül, Gülcan Coskun Akar
https://pubmed.ncbi.nlm.nih.gov/18795563Comparison of suture and sutureless techniques on postoperative complications after third molar surgery: a systematic review.
Saulo Gabriel Moreira Falci, Marco Túllio Becheleni Ávila Guimarães, Nathalia Moore Canarim...
https://pubmed.ncbi.nlm.nih.gov/38267703Cyanoacrylate versus suture as flap closure methods in mandibular third molar surgery: a split-mouth randomized controlled clinical study.
M Santmartí-Oliver, S Bazal-Bonelli, L Sánchez-Labrador...
https://pubmed.ncbi.nlm.nih.gov/38907642A comparative study of surgical drain placement and the use of kinesiologic tape to reduce postoperative morbidity after third molar surgery.
Aysenur Genc, Sirmahan Cakarer, Basak Keskin Yalcin...
https://pubmed.ncbi.nlm.nih.gov/29675759Cyanoacrylate tissue adhesive or silk suture for closure of surgical wound following removal of an impacted mandibular third molar: A randomized controlled study.
Afisu A Oladega, Olutayo James, Wasiu L Adeyemo
https://pubmed.ncbi.nlm.nih.gov/30501926Evaluation of the effectiveness of tube drain on postoperative discomfort in mandibular third molar surgery: prospective randomized split-mouth study.
Pierluigi Mariani, Dardo Menditti, Diana Russo...
https://pubmed.ncbi.nlm.nih.gov/37177802