Actively Recruiting
The Effect of Different Intracanal Medicaments on Periapical Lesion Healing
Led by Mustafa Kemal University · Updated on 2025-11-20
60
Participants Needed
1
Research Sites
80 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is planned to evaluate the effects of two different intracanal medicaments-calcium hydroxide and diclofenac sodium-on periapical healing following endodontic retreatment. Fifty-four patients will be included and randomly assigned into two groups according to the type of medicament used. All procedures will be performed by a single experienced endodontist under standardized clinical conditions. Periapical lesion healing will be assessed radiographically at baseline and after 12 months using fractal analysis to quantitatively evaluate bone regeneration. The primary outcome will be the change in the fractal dimension values between the initial and follow-up radiographs.
CONDITIONS
Official Title
The Effect of Different Intracanal Medicaments on Periapical Lesion Healing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 to 60 years
- Systemically healthy individuals classified as ASA I-II
- Presence of apical periodontitis after primary root canal treatment
- Single-rooted, root-filled mandibular teeth with a periapical index score of 3 or higher
- Initial endodontic treatment performed at least four years prior or presence of clinical symptoms and signs
- Root canal fillings with satisfactory or poor quality as defined by obturation criteria
- Indications for retreatment including post-treatment apical periodontitis, poor obturation quality, symptoms like spontaneous pain, tenderness, or sinus tract formation
You will not qualify if you...
- History of psychiatric disorders
- Allergic reactions
- Pregnancy
- Use of analgesics within seven days before treatment
- Use of antibiotics within the previous three months
- Teeth with periodontal pocket depth greater than 4 mm
- Severe coronal destruction preventing rubber dam placement
- Vertical root fracture
- Internal or external root resorption
- Ankylosis
- Overfilling or open apex
- Teeth that have undergone surgical or nonsurgical retreatment after primary therapy
- Teeth with perforation or fractured instruments
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Merve Sarı
Hatay, Antakya, Turkey (Türkiye), 31060
Actively Recruiting
Research Team
M
Merve Sarı, DDS,MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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