Comparing Effects of Bioceramic and Epoxy Resin Root Canal Sealers on Oxidative Stress in Adults with Chronic Apical Periodontitis

What this Trial Is About

Researchers are evaluating oxidative stress markers in patients with chronic apical periodontitis who undergo a single session root canal treatment using different root canal sealers. The study aims to understand if there is a change in oxidative stress markers measured from saliva after treatment and whether these changes differ between two types of root canal sealers bioceramic-based and epoxy resin-based. This investigation is important to compare how these sealers may impact the oxidative stress in patients with this dental condition. Participants will receive root canal treatment in one session using a VDW Gold Reciproc device and reciprocal files. Two groups are studied one group treated with bioceramic-based sealer and the other with epoxyamine resin-based sealer. Saliva samples will be collected twiceonce during the treatment session and again 30 days after treatment. Additionally, periapical films will be taken before treatment to determine PAI scores, which will be compared to oxidative stress markers. During the study, participants will provide saliva samples at specified times, and dental evaluations including PAI scoring will be performed. Researchers will biochemically measure oxidative stress markers from saliva and endodontium samples to assess changes over about three months. The study monitors patient health and excludes those with conditions or behaviors that could affect results. Participants are informed about procedures and will sign consent forms before starting.

Effect of Different Root Canal Sealers on Oxidative Stress Markers