Actively Recruiting
Evaluation of Oxidative Stress in Patients With Chronic Apical Periodontitis Treated With Single Session Root Canal Treatment Using Different Root Canal Sealers: in Vivo Study
Led by bengi gülgü · Updated on 2025-07-10
40
Participants Needed
1
Research Sites
10 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating oxidative stress markers in patients with chronic apical periodontitis who undergo a single session root canal treatment using different root canal sealers. The study aims to understand if there is a change in oxidative stress markers measured from saliva after treatment and whether these changes differ between two types of root canal sealers: bioceramic-based and epoxy resin-based. This investigation is important to compare how these sealers may impact the oxidative stress in patients with this dental condition. Participants will receive root canal treatment in one session using a VDW Gold Reciproc device and reciprocal files. Two groups are studied: one group treated with bioceramic-based sealer and the other with epoxyamine resin-based sealer. Saliva samples will be collected twice—once during the treatment session and again 30 days after treatment. Additionally, periapical films will be taken before treatment to determine PAI scores, which will be compared to oxidative stress markers. During the study, participants will provide saliva samples at specified times, and dental evaluations including PAI scoring will be performed. Researchers will biochemically measure oxidative stress markers from saliva and endodontium samples to assess changes over about three months. The study monitors patient health and excludes those with conditions or behaviors that could affect results. Participants are informed about procedures and will sign consent forms before starting.
CONDITIONS
Brief Title
Effect of Different Root Canal Sealers on Oxidative Stress Markers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Systemically healthy, ASA1 patients
- Phase 1 periodontal treatment was performed
- Diagnosed with chronic apical periodontitis in a single tooth with 2 or more roots
- Lesion size less than 2 cm on radiographic evaluation
- Tooth vitality checked and confirmed to be devitalised by EPT and cold test
- Socioculturally able to participate in the treatment
- Individuals who do not smoke or drink alcohol
You will not qualify if you...
- Use of antibiotics in the last three months or analgesics in the last two weeks
- Smoking or alcohol abuse
- Age younger than 18 years or older than 45 years
- Controlled or uncontrolled systemic disease and life-threatening conditions (ASA 2 and above)
- Pregnant or lactating women
- Poor oral hygiene
- History of head and neck radiotherapy
- Obesity
- Active periodontal disease
- Periodontal pocket depth over 3 mm
- Tooth with insufficient material loss preventing isolation or requiring post placement
- Symptoms in percussion-palpation of the relevant tooth
- Lesion located near mandibular canal or maxillary sinus on radiographs
- Need for prophylactic antibiotic use before invasive dental procedures
- Failure to attend follow-up or complications during treatment (e.g., instrument separation, perforation)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single session
Participants receive a single session root canal treatment using one of two different root canal sealers. Samples are collected from the root canal during the procedure to measure oxidative stress markers.
1 treatment visit (in-person)
Duration - Approximately 1 month
Participants are monitored for changes in oxidative stress markers and PAI scores using periapical films taken before treatment and assessments performed at day 1 and day 30 after treatment.
2 visits (in-person) at day 1 and day 30 post-treatment
Trial Site Locations
Total: 1 location
1
Ordu University
Ordu, Ordu- Altınordu, Turkey (Türkiye), 52200
Actively Recruiting
Research Team
B
Bengi Gülgü
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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