Actively Recruiting
Effect of Different Root Canal Sealers on Oxidative Stress Markers
Led by bengi gülgü · Updated on 2025-07-10
40
Participants Needed
1
Research Sites
86 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to primary purpose investigate and compare oxidative stress markers in patients with chronic apical periodontitis treated with different root canal paste in a single session. The main questions it aims to answer are: Is there a change in oxidative stress markers measured from saliva after root canal treatment? Is there a difference between the change of oxidative stress markers in patients using different root canal sealers after root canal treatment? Researchers will compare bioceramic-based and epoxy resin-based root canal sealers to see if there are significant differences in oxidative stress markers measured from patients' saliva after root canal treatment. * Participants will be informed about all procedures before starting the clinical process. * Participants are expected to allow saliva sampling two times: first sample will be collected on root canal treatment session and second sample will be collected on the 30th day after root canal treatment. * Participants will be informed in writing about the treatment procedure before starting the clinical process. * Participants are expected to sign the informed consent form on a voluntary basis.
CONDITIONS
Official Title
Effect of Different Root Canal Sealers on Oxidative Stress Markers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be systemically healthy (ASA1)
- Have completed phase 1 periodontal treatment
- Diagnosed with chronic apical periodontitis in a single tooth with two or more roots
- Lesion size less than 2 cm on X-ray
- Tooth confirmed devitalised by vitality tests (EPT and Cold test)
- Socioculturally able to participate in treatment
- Do not smoke or consume alcohol
You will not qualify if you...
- Use of antibiotics within the last three months or analgesics within the last two weeks
- Smoking or alcohol abuse
- Age under 18 or over 45 years
- Presence of controlled or uncontrolled systemic disease (ASA 2 or higher)
- Pregnancy or lactation
- Poor oral hygiene
- History of head and neck radiotherapy
- Obesity
- Active periodontal disease
- Periodontal pocket depth greater than 3 mm
- Tooth damage preventing proper isolation or requiring post placement
- Symptoms on percussion-palpation exam of the tooth
- Lesion near important anatomical structures on X-ray
- Need for prophylactic antibiotics before dental procedures
- Failure to attend follow-up or complications such as instrument separation or perforation during treatment
AI-Screening
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Trial Site Locations
Total: 1 location
1
Ordu University
Ordu, Ordu- Altınordu, Turkey (Türkiye), 52200
Actively Recruiting
Research Team
B
Bengi Gülgü
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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