Actively Recruiting
Effect Of Different Sodium Hypochlorite Concentrations On Intracanal Substance P, CGRP And Opiorphin Levels And Postoperative Pain During Root Canal Retreatment
Led by KEZBAN MELTEM ÇOLAK · Updated on 2026-03-06
60
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized clinical study aims to evaluate the effect of different sodium hypochlorite concentrations (1%, 2.5%, and 5.25%) used during root canal retreatment on intracanal levels of Substance P, CGRP, and Opiorphin, as well as postoperative pain. Patients requiring non-surgical root canal retreatment will be randomly assigned to one of three irrigation concentration groups. Intracanal samples will be collected before and after irrigation to measure neuropeptide levels. Postoperative pain will be assessed using a visual analog scale (VAS) at predetermined time intervals. The results of this study may help clarify the relationship between irrigant concentration, inflammatory mediators, and postoperative pain following root canal retreatment.
CONDITIONS
Official Title
Effect Of Different Sodium Hypochlorite Concentrations On Intracanal Substance P, CGRP And Opiorphin Levels And Postoperative Pain During Root Canal Retreatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged between 18 and 65 years
- Systemically healthy individuals (ASA I or II)
- Patients requiring non-surgical root canal retreatment of a previously treated permanent tooth
- Patients who provide written informed consent.
You will not qualify if you...
- Patients with systemic diseases affecting pain or inflammation
- Use of analgesics, anti-inflammatory drugs, or antibiotics within 7 days prior to treatment
- Pregnant or lactating women
- Teeth with root fractures, perforations, advanced periodontal disease, or non-restorable
- Teeth with open apices or immature root development
- Presence of acute apical abscess with swelling or sinus tract
- Known allergy to sodium hypochlorite
- Inability to achieve adequate isolation with rubber dam
- Patients unable to attend follow-up or complete pain assessments
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Atatürk University Faculty of Dentistry, Department of Endodontics
Erzurum, Erzurum, Turkey (Türkiye), 25240
Actively Recruiting
Research Team
K
KEZBAN MELTEM ÇOLAK, Prof. Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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