Actively Recruiting
Effect of Dotinurad in Hyperuricemia With Hypertension
Led by Saga University · Updated on 2025-12-15
360
Participants Needed
1
Research Sites
261 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The effect of dotinurad on CAVI (cardio-ankle vascular index) will be compared with that of febuxostat in patients with hyperuricemia complicated by hypertension.
CONDITIONS
Official Title
Effect of Dotinurad in Hyperuricemia With Hypertension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 20 years or older at the time of consent (all genders)
- Hyperuricemia with serum uric acid level greater than 7.0 mg/dL
- No urate lowering drug use within 27 days prior to consent, or off such drugs for more than 27 days if previously treated
- Hypertensive patients meeting the latest Japanese Society of Hypertension definition
- Stable hypertension treatment without changes in the 4 weeks before eligibility
- Provided written consent to participate in the study
You will not qualify if you...
- Unsettled gout after acute gouty arthritis
- Current urinary tract stones
- Known secondary hyperuricemia due to specific syndromes or diseases including Lesch-Nyhan syndrome, hematopoietic tumors, solid tumors, and others listed
- Hypertensive emergencies or urgency
- Active malignancies
- Severe liver dysfunction
- Severe kidney dysfunction with oliguria or anuria
- Pregnant, possibly pregnant, or lactating
- History of hypersensitivity to dotinurad or febuxostat
- Receiving mercaptopurine hydrate or azathioprine
- Any other condition deemed inappropriate by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Saga University
Saga, Saga-ken, Japan, 840-8502
Actively Recruiting
Research Team
K
Koichi Koichi, Pr.,Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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