Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07408375

Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology

Led by Nantes University Hospital · Updated on 2026-03-27

560

Participants Needed

7

Research Sites

104 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Tumor thermal ablation under Jet Ventilation is a procedure performed under general anesthesia that enables tumor ablation under radiological imaging guidance. This procedure, being less invasive than conventional surgery, allows for a faster recovery and hospital discharge. This procedure requires significant precision to ensure the most complete destruction of the tumor, while also preserving adjacent organs. During general anesthesia, respiratory movements complicate radiological localization and tumor destruction. The principle of High-Frequency Jet Ventilation (HFJV) involves using a device that ventilates a small volume of air and oxygen at a specific pressure, called driving pressure, at a high frequency. This ventilation mode reduces respiratory movements while ensuring continuous ventilation and oxygenation. This respiratory stability allows for the precision necessary to superimpose images for tumor localization and destruction. There are no guidelines regarding the driving pressure setting for HFJV for tumor thermal ablation. The method tested in this research is based on patient's height to optimize the driving pressure when using HFV. The main objective of this research is to evaluate the impact of driving pressure settings, on respiratory function, taking into account patient's height. On the day of the procedure, the driving pressure setting for the HFJV will be randomly assigned (1.4 bars, 1.9 bars, 2.4 bars, or customized according to the patient's height) (1 bar = 14 psi). The research will be conducted using medical data collected during routine patient care. Patient participation will last for the duration of their hospital stay, approximately two days.

CONDITIONS

Official Title

Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Undergoing thermal ablation of a solid tumor using High-Frequency Jet Ventilation
  • Provided informed consent to participate
  • Covered by a social security scheme
Not Eligible

You will not qualify if you...

  • Under legal guardianship or curatorship
  • Does not understand French
  • Pregnant or breastfeeding
  • History of pneumonectomy
  • Requires an endotracheal tube smaller than size 6.5

AI-Screening

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Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 7 locations

1

CHU de Lyon

Lyon, France, 69002

Not Yet Recruiting

2

Centre Léon Bérard

Lyon, France, 69008

Not Yet Recruiting

3

CHU de Nantes

Nantes, France, 44093

Actively Recruiting

4

CHU de Nîmes

Nîmes, France, 30900

Not Yet Recruiting

5

CHU de Poitiers

Poitiers, France, 86000

Not Yet Recruiting

6

ICO Unicancer

Saint-Herblain, France, 44800

Not Yet Recruiting

7

Institut Gustave Roussy

Villejuif, France, 94800

Actively Recruiting

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Research Team

N

Nathalie DESFRICHES-DORIA

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

4

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