Actively Recruiting
Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology
Led by Nantes University Hospital · Updated on 2026-03-27
560
Participants Needed
7
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Tumor thermal ablation under Jet Ventilation is a procedure performed under general anesthesia that enables tumor ablation under radiological imaging guidance. This procedure, being less invasive than conventional surgery, allows for a faster recovery and hospital discharge. This procedure requires significant precision to ensure the most complete destruction of the tumor, while also preserving adjacent organs. During general anesthesia, respiratory movements complicate radiological localization and tumor destruction. The principle of High-Frequency Jet Ventilation (HFJV) involves using a device that ventilates a small volume of air and oxygen at a specific pressure, called driving pressure, at a high frequency. This ventilation mode reduces respiratory movements while ensuring continuous ventilation and oxygenation. This respiratory stability allows for the precision necessary to superimpose images for tumor localization and destruction. There are no guidelines regarding the driving pressure setting for HFJV for tumor thermal ablation. The method tested in this research is based on patient's height to optimize the driving pressure when using HFV. The main objective of this research is to evaluate the impact of driving pressure settings, on respiratory function, taking into account patient's height. On the day of the procedure, the driving pressure setting for the HFJV will be randomly assigned (1.4 bars, 1.9 bars, 2.4 bars, or customized according to the patient's height) (1 bar = 14 psi). The research will be conducted using medical data collected during routine patient care. Patient participation will last for the duration of their hospital stay, approximately two days.
CONDITIONS
Official Title
Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Undergoing thermal ablation of a solid tumor using High-Frequency Jet Ventilation
- Provided informed consent to participate
- Covered by a social security scheme
You will not qualify if you...
- Under legal guardianship or curatorship
- Does not understand French
- Pregnant or breastfeeding
- History of pneumonectomy
- Requires an endotracheal tube smaller than size 6.5
AI-Screening
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Trial Site Locations
Total: 7 locations
1
CHU de Lyon
Lyon, France, 69002
Not Yet Recruiting
2
Centre Léon Bérard
Lyon, France, 69008
Not Yet Recruiting
3
CHU de Nantes
Nantes, France, 44093
Actively Recruiting
4
CHU de Nîmes
Nîmes, France, 30900
Not Yet Recruiting
5
CHU de Poitiers
Poitiers, France, 86000
Not Yet Recruiting
6
ICO Unicancer
Saint-Herblain, France, 44800
Not Yet Recruiting
7
Institut Gustave Roussy
Villejuif, France, 94800
Actively Recruiting
Research Team
N
Nathalie DESFRICHES-DORIA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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