Actively Recruiting
Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Resuscitation in Septic Shock: Pilot Study
Led by Mahidol University · Updated on 2025-04-27
60
Participants Needed
3
Research Sites
154 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To investigate the benefit of using the AFM and Eadyn-guided fluid and vasopressor therapy in septic shock resuscitation for mechanically ventilated patients compared with the standard of care. The investigators hypothesize that using the AFM and Eadyn-guided fluid/vasopressor titration in septic shock patients who underwent mechanical ventilation might reduce the time to shock reversal.
CONDITIONS
Official Title
Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Resuscitation in Septic Shock: Pilot Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged older than 18 years with sepsis or septic shock and mean arterial pressure less than 65 mmHg within 24 hours of shock onset
- Currently receiving or planning to receive mechanical ventilation
- Currently receiving or planning to have arterial catheter placement for invasive blood pressure monitoring
- Echocardiogram showing left ventricular ejection fraction greater than 30%
You will not qualify if you...
- Life-threatening cardiac arrhythmias such as ventricular tachycardia or ventricular fibrillation
- Acute stroke or brain hemorrhage
- Acute coronary syndrome
- Cardiogenic shock or acute heart failure
- Severe asthma attack
- Fluid intolerance with hypoxemia (P:F ratio less than 150)
- Life-threatening gastrointestinal bleeding
- Pregnancy
- Need for immediate surgery within 2 hours of randomization
- Advanced cancer with expected survival less than 6 months
- Oliguric acute kidney injury with signs of fluid overload
- Patient or legal representative requests withdrawal
- Attending physician requests withdrawal
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Faculty of Medicine Siriraj Hospital
Bangkok Noi, Bangkok, Thailand, 10700
Not Yet Recruiting
2
Siriraj Hospital, Mahidol University
Bangkok, Thailand, 10700
Actively Recruiting
3
Siriraj Hospital, Mahidol University
Bangkok, Thailand, 10700
Actively Recruiting
Research Team
R
Ranistha Ratanarat, MD
CONTACT
N
Nuwara Pornawalai, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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