Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT05920109

EffecT of eARly analGesia With Erector Spinae Plane Block to Reduce Ventilation After Severe Chest Trauma

Led by University Hospital, Grenoble · Updated on 2025-10-07

400

Participants Needed

14

Research Sites

192 weeks

Total Duration

On this page

Sponsors

U

University Hospital, Grenoble

Lead Sponsor

U

University Hospital, Clermont-Ferrand

Collaborating Sponsor

AI-Summary

What this Trial Is About

Blunt chest trauma is commonly associated with rib fractures and early pain management is a key goal after chest trauma. In spontaneous breathing patients, pain limits coughing efficiency and secretion clearance, thereby potentially leading to progressive atelectasis, loss of functional residual capacity (FRC) and, ultimately, respiratory distress. In patients under mechanical ventilation, pain interacts with the weaning of mechanical ventilation inducing an increase of the duration of invasive ventilation. According to recent French guidelines for chest trauma management, immediate analgesia is initially performed by intravenous multimodal analgesia followed by a thoracic epidural analgesia or a paravertebral block if the pain is not controlled within the first 12 hours. However, these blocks necessitate an experienced anaesthesiologist, are at risk of severe complications and are contraindicated in case of post-traumatic coagulopathy. All these considerations limit their indication in the trauma bay. The erector spinae plane (ESP) block is an easy to perform, ultrasound guided, regional anaesthesia for pain management after thoracic surgery. This block can be made continuously with a dedicated catheter for a continuous infusion of local anaesthetic drug with boli. The ESP block is performed by depositing the local anaesthetic in the fascial plane, deeper than the erector spinae muscle at the tip of the transverse process of the vertebra. This block is less invasive with fewer contraindications as compared to epidural analgesia or paravertebral blocks. After chest trauma, ESP block was associated with an improvement in respiratory capacity in a retrospective study. However, there is no randomised control trial assessing ESP efficacy. Our hypothesis is that early continuous ESP block in the trauma bay decreases the number of days with invasive and/or non-invasive ventilation after chest trauma.

CONDITIONS

Official Title

EffecT of eARly analGesia With Erector Spinae Plane Block to Reduce Ventilation After Severe Chest Trauma

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age > 18 years
  • Blunt chest trauma with 3 or more rib fractures on Thoracic CT scan
  • Spontaneous breathing or under mechanical ventilation in the trauma bay
  • Requiring an intensive or intermediate care unit admission
Not Eligible

You will not qualify if you...

  • Pre-hospital cardiac arrest
  • Patient not expected to survive within the first 72 hours
  • Uncontrolled haemodynamic instability despite initial resuscitation (systolic arterial blood pressure lower than 90 mmHg at the time of catheter insertion)
  • Mechanical ventilation for severe traumatic brain injury (Abbreviated Injury Score, AIS, head > 2)
  • Spinal cord injury at the cervical or thoracic levels
  • Hypovolaemia
  • Hypersensitivity to ropivacaine or other amide-bound local anaesthetics
  • Subject in exclusion period of another interventional study
  • Pregnant or breastfeeding women

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 14 locations

1

CHU Bordeaux - Pellegrin

Bordeaux, France, 33000

Actively Recruiting

2

Hôpital d'instruction des armées Percy

Clamart, France, 92140

Actively Recruiting

3

CHU Clermont-Ferrand

Clermont-Ferrand, France, 63000

Actively Recruiting

4

Hopital Beaujon - AP-HP

Clichy, France, 92118

Actively Recruiting

5

CH Annecy Genevois

Épagny, France, 74370

Actively Recruiting

6

CHU Grenoble Alpes

Grenoble, France, 38049

Actively Recruiting

7

CHU de Lille

Lille, France, 59000

Actively Recruiting

8

Hôpital Pitie Salpetriere - AP-HP

Paris, France, 75013

Actively Recruiting

9

Hôpital Européen Georges Pompidou - AH-HP

Paris, France, 75015

Actively Recruiting

10

Hôpital Lyon Sud

Pierre-Bénite, France, 69310

Actively Recruiting

11

Hôpital d'Instruction des Armées Sainte Anne

Toulon, France, 83000

Actively Recruiting

12

Chu Toulouse - Hopital Rangueil

Toulouse, France, 31059

Actively Recruiting

13

Chu Toulouse - Hopital Purpan

Toulouse, France, 69003

Actively Recruiting

14

CHRU Hôpitaux De Tours

Tours, France, 37000

Actively Recruiting

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Research Team

B

BOUZAT Pierre, MD, PhD

CONTACT

A

ADOLLE Anaïs

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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