Actively Recruiting
EffecT of eARly analGesia With Erector Spinae Plane Block to Reduce Ventilation After Severe Chest Trauma
Led by University Hospital, Grenoble · Updated on 2025-10-07
400
Participants Needed
14
Research Sites
192 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Grenoble
Lead Sponsor
U
University Hospital, Clermont-Ferrand
Collaborating Sponsor
AI-Summary
What this Trial Is About
Blunt chest trauma is commonly associated with rib fractures and early pain management is a key goal after chest trauma. In spontaneous breathing patients, pain limits coughing efficiency and secretion clearance, thereby potentially leading to progressive atelectasis, loss of functional residual capacity (FRC) and, ultimately, respiratory distress. In patients under mechanical ventilation, pain interacts with the weaning of mechanical ventilation inducing an increase of the duration of invasive ventilation. According to recent French guidelines for chest trauma management, immediate analgesia is initially performed by intravenous multimodal analgesia followed by a thoracic epidural analgesia or a paravertebral block if the pain is not controlled within the first 12 hours. However, these blocks necessitate an experienced anaesthesiologist, are at risk of severe complications and are contraindicated in case of post-traumatic coagulopathy. All these considerations limit their indication in the trauma bay. The erector spinae plane (ESP) block is an easy to perform, ultrasound guided, regional anaesthesia for pain management after thoracic surgery. This block can be made continuously with a dedicated catheter for a continuous infusion of local anaesthetic drug with boli. The ESP block is performed by depositing the local anaesthetic in the fascial plane, deeper than the erector spinae muscle at the tip of the transverse process of the vertebra. This block is less invasive with fewer contraindications as compared to epidural analgesia or paravertebral blocks. After chest trauma, ESP block was associated with an improvement in respiratory capacity in a retrospective study. However, there is no randomised control trial assessing ESP efficacy. Our hypothesis is that early continuous ESP block in the trauma bay decreases the number of days with invasive and/or non-invasive ventilation after chest trauma.
CONDITIONS
Official Title
EffecT of eARly analGesia With Erector Spinae Plane Block to Reduce Ventilation After Severe Chest Trauma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years
- Blunt chest trauma with 3 or more rib fractures on Thoracic CT scan
- Spontaneous breathing or under mechanical ventilation in the trauma bay
- Requiring an intensive or intermediate care unit admission
You will not qualify if you...
- Pre-hospital cardiac arrest
- Patient not expected to survive within the first 72 hours
- Uncontrolled haemodynamic instability despite initial resuscitation (systolic arterial blood pressure lower than 90 mmHg at the time of catheter insertion)
- Mechanical ventilation for severe traumatic brain injury (Abbreviated Injury Score, AIS, head > 2)
- Spinal cord injury at the cervical or thoracic levels
- Hypovolaemia
- Hypersensitivity to ropivacaine or other amide-bound local anaesthetics
- Subject in exclusion period of another interventional study
- Pregnant or breastfeeding women
AI-Screening
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Trial Site Locations
Total: 14 locations
1
CHU Bordeaux - Pellegrin
Bordeaux, France, 33000
Actively Recruiting
2
Hôpital d'instruction des armées Percy
Clamart, France, 92140
Actively Recruiting
3
CHU Clermont-Ferrand
Clermont-Ferrand, France, 63000
Actively Recruiting
4
Hopital Beaujon - AP-HP
Clichy, France, 92118
Actively Recruiting
5
CH Annecy Genevois
Épagny, France, 74370
Actively Recruiting
6
CHU Grenoble Alpes
Grenoble, France, 38049
Actively Recruiting
7
CHU de Lille
Lille, France, 59000
Actively Recruiting
8
Hôpital Pitie Salpetriere - AP-HP
Paris, France, 75013
Actively Recruiting
9
Hôpital Européen Georges Pompidou - AH-HP
Paris, France, 75015
Actively Recruiting
10
Hôpital Lyon Sud
Pierre-Bénite, France, 69310
Actively Recruiting
11
Hôpital d'Instruction des Armées Sainte Anne
Toulon, France, 83000
Actively Recruiting
12
Chu Toulouse - Hopital Rangueil
Toulouse, France, 31059
Actively Recruiting
13
Chu Toulouse - Hopital Purpan
Toulouse, France, 69003
Actively Recruiting
14
CHRU Hôpitaux De Tours
Tours, France, 37000
Actively Recruiting
Research Team
B
BOUZAT Pierre, MD, PhD
CONTACT
A
ADOLLE Anaïs
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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