Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07519512

Effect of Early Transition to Assisted Ventilation on 28-day Successful Extubation in Critically Ill Patients

Led by Southeast University, China · Updated on 2026-04-23

1600

Participants Needed

1

Research Sites

230 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

EARLY-VENT is a multicenter, open-label, three-period cluster-randomized crossover trial designed to evaluate whether early transition from controlled to assisted ventilation improves outcomes in critically ill patients. The study will enroll approximately 1,600 adult patients across 10 ICUs who are expected to require mechanical ventilation for at least 48 hours and meet specific stability criteria (e.g., hemodynamically stable, light sedation). Participating centers will alternate between an experimental strategy, where patients transition to an assisted mode (preferably Pressure Support Ventilation) within 6 hours of eligibility, and a control strategy based on standard care practices. The primary endpoint is the rate of successful extubation at day 28, aiming to demonstrate that transition from controlled to assisted ventilation can reduce ventilation duration and improve prognosis compared to delayed transition.

CONDITIONS

Official Title

Effect of Early Transition to Assisted Ventilation on 28-day Successful Extubation in Critically Ill Patients

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Expected ICU stay and mechanical ventilation for at least 48 hours
  • Receiving controlled ventilation mode
  • No neuromuscular blocking agents in use
  • Sedation level with RASS -3 or higher
  • P/F ratio 150 mmHg or higher
Not Eligible

You will not qualify if you...

  • Severe end-stage irreversible respiratory, cardiac, or neurologic diseases that may cause long-term ventilator dependence or inability to wean
  • Expected death or ICU transfer within 48 hours
  • Hemodynamic instability as judged by clinician
  • Pregnancy
  • Participation in other mechanical ventilation clinical studies
  • Any condition deemed unsuitable for participation by the investigator

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

Zhongda Hospital, School of Medicine, Southeast University

Nanjing, Jiangsu, China, 210009

Actively Recruiting

Loading map...

Research Team

J

Jie Wu

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

TREATMENT

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here