Actively Recruiting
Effect of Ebastine in Patients With Diarrhea Predominant Irritable Bowel Syndrome
Led by Md. Hazrat Ali · Updated on 2025-08-20
60
Participants Needed
1
Research Sites
45 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to assess and compare the effect of ebastine and placebo in improving symptoms in patients with diarrhea predominant IBS. It will also assess about the safety of drugs ebastine and placebo by recording the patient reported adverse events. The main questions it aim to answer are: Does drug ebastine and placebo has any effect on patients with IBS-D? What medical problems do participants have when taking drug ebastine and placebo? Researcher will compare effect of drug ebastine and placebo . Participant will: Take drug ebastine 20 mg at night and placebo once daily at night every day for 8 weeks along with lifestyle modifications. After that all two groups will visit the hospital 4 weekly, and their symptoms will be assessed by IBS symptom severity score (IBS-SSS) at baseline, week 4 and week 8. Additionally, patient reported adverse events will be documented.
CONDITIONS
Official Title
Effect of Ebastine in Patients With Diarrhea Predominant Irritable Bowel Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 and above
- Patients who meet the Rome IV criteria for IBS-D.
You will not qualify if you...
- Presence of alarm features: anemia, weight loss, per rectal bleeding, nocturnal frequency, and family history of colonic cancer
- History of major gastrointestinal surgery
- Medical disease that affect the digestive system, such as uncontrolled diabetes, hyperthyroidism, hypothyroidism
- Pregnant and lactating women
- Vehicle drivers, mechanical operators and aerial operators
- Drug abuse or alcohol abuse
AI-Screening
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Trial Site Locations
Total: 1 location
1
Dhaka Medical College
Dhaka, Bangladesh
Actively Recruiting
Research Team
M
Md. Hazrat Ali, MBBS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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