Comparing EIT-Guided and FiO2-PEEP Table Methods for Setting PEEP in Moderate to Severe ARDS Patients A Multicenter Randomized Controlled Trial on Clinical Outcomes

What this Trial Is About

Acute Respiratory Distress Syndrome ARDS is a serious condition with a high risk of death. Mechanical ventilation is the main treatment for ARDS but can sometimes cause additional lung injury. This study evaluates how using Electrical Impedance Tomography EIT, a bedside imaging tool, to guide the setting of positive end-expiratory pressure PEEP compares to using a standard oxygen and PEEP table in patients with moderate to severe ARDS. Participants will be randomly assigned to one of two groups. One group will have their PEEP levels adjusted using EIT through a stepwise decrease trial starting from higher pressures. The other group will have their PEEP set based on a lower PEEP and oxygen FiO2 table aiming to maintain oxygen levels within a specific range. Treatments will be delivered while participants are mechanically ventilated. During the study, participants will be monitored for clinical outcomes including mortality at 28 days. Researchers will assess oxygenation and lung function under the different PEEP settings. The trial is designed to compare the effects of the EIT-guided PEEP method versus the standard care approach. The total participation duration and follow-up will cover the critical period of ARDS management under mechanical ventilation.

Effect of EIT-guided PEEP in ARDS Patients