Actively Recruiting
THE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE
Led by Postgraduate Institute of Dental Sciences Rohtak · Updated on 2026-01-15
80
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Study subjects were obtained from the pool of OPD patients in the Department of Conservative Dentistry and Endodontics, PGIDS, Rohtak, and the Department of Cardiology, PGIMS, Rohtak. Baseline clinical, radiographic, and laboratory parameters (hsCRP and IL-6) were recorded. Patients were then randomly allocated to one of the two groups. In the test group, single-sitting root canal treatment was performed immediately, while in the control group, delayed endodontic intervention (after 3 months) was performed after three months. Clinical and laboratory parameters were again assessed at the end of 3 months in both groups. hsCRP and IL-6 indices were again done in the delayed treatment group after 3 months of root canal treatment.
CONDITIONS
Official Title
THE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals 30 years of age and older with stable coronary artery disease (CAD) and chronic apical periodontitis
- CAD diagnosis confirmed by the Brazilian Society of Cardiology criteria, including history of myocardial infarction, stable angina, ischemia on tests, revascularization, or significant coronary artery lesion
- Presence of apical periodontitis with at least one radiographic radiolucency of 3mm or more on a permanent tooth, with pulp necrosis confirmed by cold and electric pulp tests
You will not qualify if you...
- Chronic conditions affecting periodontitis or systemic inflammation such as diabetes, rheumatoid arthritis, rheumatic fever, cancer, respiratory or kidney diseases
- Presence of localized or widespread periodontal disease
- Acute symptomatic patients
- History of smoking
- Acute conditions affecting systemic inflammation such as orthopedic trauma, surgery, or viral infections
- Use of medications in the last 3 months that affect inflammation markers, including systemic steroids, immunosuppressants, hormone replacement therapy, contraceptives, or antibiotics
- Obesity with body mass index (BMI) of 30 kg/m2 or higher
- Pregnancy and lactation
AI-Screening
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Trial Site Locations
Total: 1 location
1
Post Graduate institute of Dental Sciences, Rohtak
Rohtak, Haryana, India, 124001
Actively Recruiting
Research Team
N
Nishant Chauhan, MDS
CONTACT
S
Shweta Mittal, MDS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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