Study of Root Canal Treatment Timing on Heart Disease Risk Markers in Patients with Stable Coronary Artery Disease and Apical Periodontitis

What this Trial Is About

Researchers are studying the effect of root canal treatment on cardiovascular risk markers in patients with stable coronary artery disease CAD who also have chronic apical periodontitis. This randomized controlled trial aims to compare immediate versus delayed root canal treatment and assess how these treatments influence levels of inflammatory markers, specifically hs-CRP and IL-6, which are associated with cardiovascular risk. Patients with CAD defined by specific clinical and imaging criteria are included to better understand the interaction between dental infection and heart disease. Participants are randomly assigned to one of two groups one group receives immediate single-sitting root canal treatment right after diagnosis, while the other group has delayed treatment performed three months later. The root canal procedure involves accessing the tooth, cleaning and shaping the canals with specific instruments, irrigating with a sodium hypochlorite solution, drying, and filling the canals with gutta-percha and a zinc oxide eugenol-based sealer. The trial monitors these groups over a three-month period after treatment. Throughout the study, clinical, radiographic, and laboratory assessments, including measuring hs-CRP and IL-6 levels, are conducted at baseline and after three months in both groups. The delayed treatment group undergoes an additional measurement of these markers three months following their root canal therapy. This allows researchers to evaluate changes in cardiovascular risk biomarkers related to the timing of endodontic treatment. The total participation duration spans at least three months with careful monitoring of inflammatory markers to assess outcomes.

THE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE