Actively Recruiting
The Effect of Endodontic Treatment on Cardiovascular Risk Biomarkers in Patients with Stable Coronary Artery Disease: A Randomized Controlled Trial
Led by Postgraduate Institute of Dental Sciences Rohtak · Updated on 2026-01-15
80
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effect of root canal treatment on cardiovascular risk markers in patients with stable coronary artery disease (CAD) who also have chronic apical periodontitis. This randomized controlled trial aims to compare immediate versus delayed root canal treatment and assess how these treatments influence levels of inflammatory markers, specifically hs-CRP and IL-6, which are associated with cardiovascular risk. Patients with CAD defined by specific clinical and imaging criteria are included to better understand the interaction between dental infection and heart disease. Participants are randomly assigned to one of two groups: one group receives immediate single-sitting root canal treatment right after diagnosis, while the other group has delayed treatment performed three months later. The root canal procedure involves accessing the tooth, cleaning and shaping the canals with specific instruments, irrigating with a sodium hypochlorite solution, drying, and filling the canals with gutta-percha and a zinc oxide eugenol-based sealer. The trial monitors these groups over a three-month period after treatment. Throughout the study, clinical, radiographic, and laboratory assessments, including measuring hs-CRP and IL-6 levels, are conducted at baseline and after three months in both groups. The delayed treatment group undergoes an additional measurement of these markers three months following their root canal therapy. This allows researchers to evaluate changes in cardiovascular risk biomarkers related to the timing of endodontic treatment. The total participation duration spans at least three months with careful monitoring of inflammatory markers to assess outcomes.
CONDITIONS
Brief Title
THE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals 30 years of age and older with stable coronary artery disease and chronic apical periodontitis
- Documented CAD within past 6 months as defined by history of myocardial infarction, stable angina, ischemia in tests, revascularization, or major artery lesion over 50%
- At least one permanent tooth with apical periodontitis showing radiolucency of 3mm or more and pulp necrosis confirmed by tests
You will not qualify if you...
- Chronic conditions affecting inflammation such as diabetes, rheumatoid arthritis, rheumatic fever, malignancy, respiratory or renal diseases
- Presence of localized or diffuse periodontal disease
- Acute symptomatic patients
- History of smoking as a cardiovascular risk factor
- Acute conditions affecting inflammatory markers like trauma, surgery, or viral infections
- Use of steroids, immunosuppressants, hormone therapy, contraceptives, or antibiotics in last 3 months
- Obesity with BMI of 30 kg/m2 or higher
- Pregnancy or lactation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Immediate or delayed by 3 months
Participants receive root canal treatment for apical periodontitis either immediately after diagnosis or after a 3-month delay.
1 root canal treatment visit
Duration - 3 months
Participants are monitored for changes in cardiovascular risk biomarkers over 3 months after treatment.
Periodic visits to assess biomarker levels
Trial Site Locations
Total: 1 location
1
Post Graduate institute of Dental Sciences, Rohtak
Rohtak, Haryana, India, 124001
Actively Recruiting
Research Team
N
Nishant Chauhan, MDS
S
Shweta Mittal, MDS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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