Status Unknown
Effect of Esketamine on Conscious State in Patients With Prolonged Disorders of Consciousnessa Prospective, Randomized, Exploratory Study
Led by Beijing Tiantan Hospital · Updated on 2024-07-30
116
Participants Needed
1
Research Sites
25 weeks
Total Duration
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn about the effect of intraoperative infusion of subanesthetic dose of esketamine on conscious status in patients with prolonged disorders of consciousness under sevoflurane anesthesia. Participants will be patients with prolonged disorders of consciousness undergoing surgery with general anesthesia at Beijing Tiantan Hospital. 0.3mg/kg esketamine or saline will be infused will be infused intravenously at a constant speed within 30 min after tracheal intubation/pneumatectomy fixation. Coma recovery scale-revised, Glasgow coma scale, Full Outline of UnResponsiveness scores, SedLine multi-channel electroencephalogram and perioperative adverse events after surgery will be investigated.
CONDITIONS
Brief Title
Effect of Esketamine on Conscious State in Patients With pDoC
Research Team
R
Ruquan Han, M.D
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