Actively Recruiting
Effect of Esketamine and Lidocaine on Postoperative Chronic Pain and Long-term Survival in Patients Undergoing Hepatectomy
Led by West China Hospital · Updated on 2025-01-16
304
Participants Needed
1
Research Sites
203 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a further observation and follow-up of the patients enrolled in the registration number ChiCTR230007164430 to further evaluate the effect of long-term infusion of esketamine and lidocaine on postoperative chronic pain, long-term quality of life and survival rate in patients undergoing hepatectomy.
CONDITIONS
Official Title
Effect of Esketamine and Lidocaine on Postoperative Chronic Pain and Long-term Survival in Patients Undergoing Hepatectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18-75 years
- Scheduled for elective hepatectomy
- ASA grade I-III
You will not qualify if you...
- Patients intubated in ICU after surgery without planned extubation within 6 hours postoperatively
- Body weight under 40 kg or over 100 kg
- Cardiac conduction abnormalities (second- or third-degree atrioventricular block) or cardiac insufficiency with left ventricular ejection fraction below 50%
- Severe liver insufficiency with ALT, AST, or bilirubin levels more than 2.5 times the upper limit of normal
- Renal insufficiency with creatinine clearance under 60 mL/min
- Known allergy to esketamine or lidocaine
- History of long-term opioid abuse
- Unable to communicate effectively
- Serious medical conditions like uncontrolled hypertension, coronary heart disease, intracranial vascular malformations, or acute asthma attacks
- History of epilepsy or manic episodes
- Pregnant or breastfeeding women
- Glaucoma
- Preoperative cognitive dysfunction, bipolar disorder, or other psychiatric disorders including mental retardation
- Primary liver cancer with other malignant tumors or signs of distant metastasis
AI-Screening
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Trial Site Locations
Total: 1 location
1
West China Hospital
Chengdu, Sichuan, China
Actively Recruiting
Research Team
C
Chunling Jiang, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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