Actively Recruiting
The Effect of Exercise on the Brain in Type 2 Diabetes
Led by Hasselt University · Updated on 2026-03-31
75
Participants Needed
1
Research Sites
142 weeks
Total Duration
On this page
Sponsors
H
Hasselt University
Lead Sponsor
U
Universitaire Ziekenhuizen KU Leuven
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if exercise training of high or moderate intensity is most optimal to improve brain health and prevent neurodegeneration in type 2 diabetes patients. The main question it aims to answer is: What is the effect of exercise training of high vs. moderate intensity on brain metabolism, brain perfusion, and cognition in type 2 diabetes? Researchers will compare the exercise training groups to a control group without exercise training to determine the effect of exercise training on the brain in type 2 diabetes. Participants will exercise for 6 months, 3 times per week. Before and after these 6 months, they will undergo: * a brain MRI scan * cognitive tests * blood sampling
CONDITIONS
Official Title
The Effect of Exercise on the Brain in Type 2 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of type 2 diabetes
- Not using insulin therapy
- Age between 30 and 75 years
- Physically inactive
You will not qualify if you...
- Having any contraindications for MRI scans
- Psychological disorders
- Using exogenous insulin therapy
- History of coma, transient ischemic attack, head trauma, brain tumor, stroke, epilepsy, or other central nervous system diseases causing dementia or having dementia before type 2 diabetes
- Any disease significantly affecting ability to participate in exercise, such as chronic heart disease (e.g., valve insufficiency grade 2 or higher), significant arrhythmias, recent cardiac events (within one year), clinical heart failure, chronic obstructive pulmonary disease, cerebrovascular or peripheral vascular disease
- Severe hypertension (greater than 160/110 mmHg)
- Ongoing cancer
- Severe neuropathy limiting exercise participation
- Renal disease with glomerular filtration rate below 45 ml/min/1.73 m2
- Inability to regularly participate in the exercise program
- Pregnancy
- Breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hasselt University
Hasselt, Limburg, Belgium, 3500
Actively Recruiting
Research Team
D
Dominique Hansen, Full Professor
CONTACT
J
Jitske Vandersmissen, PhD student
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here