Study of Exercise Impact on Reducing Antipsychotic Medication in Adults With Psycho-Cardiological Disease A Multicenter Randomized Controlled Clinical Trial

What this Trial Is About

This trial focuses on the complex relationship between cardiovascular diseases and emotional disorders such as depression and anxiety, conditions that often occur together and increase risks for patients. Researchers aim to study whether adding exercise therapy to antipsychotic treatment can help reduce medication dosage and withdrawal time in patients with both cardiovascular disease and depression or anxiety. This research is important because current drug treatments have side effects and high recurrence rates, while exercise offers a potentially safer option with additional benefits. Participants are divided into two groups one receives regular antipsychotic medications, including sertraline, escitalopram, fluoxetine, duloxetine, paroxetine, venlafaxine, and fluvoxamine, while the other group receives the same medications plus a moderate-intensity continuous exercise program. The exercise involves at least 36 sessions over 12 weeks, performed three times per week with warm-up, training at 70% to 85% heart rate reserve, and cool-down periods. The exercise plan is personalized and adjusted based on each patients aerobic capacity and fatigue levels. During the study, participants medication doses are monitored at baseline and after 12 weeks to assess changes. Researchers also evaluate depression and anxiety symptoms, stress levels, sleep quality, quality of life, withdrawal symptoms, cardiopulmonary fitness, recurrence of mood symptoms, heart function via electrocardiogram, and blood tests at multiple time points up to 2 years after intervention. Regular follow-ups and doctor visits every two weeks support medication management and safety. The study lasts for at least 12 weeks of intervention with extended monitoring for long-term outcomes.

Effect of Exercise on Tapering Antipsychotics in Patients With Psycho-cardiological Disease(EXTRA-study)