Actively Recruiting
Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes
Led by University of Cincinnati · Updated on 2024-09-03
10
Participants Needed
1
Research Sites
272 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D). In a previous study, it was observed in people without diabetes that fasting can be detrimental to the hormonal and hepatic responses to insulin-induced hypoglycemia. In the experiments described herein, the impact fasting has on hypoglycemic counterregulation in people with T1D will be determined.
CONDITIONS
Official Title
Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females of any race or ethnicity
- Non-obese with BMI less than or equal to 30
- Diagnosis of type 1 diabetes
- C-peptide negative
You will not qualify if you...
- Pregnant women
- Cigarette smokers
- Taking inflammation-targeting steroids (e.g., prednisone)
- Taking medications targeting adrenergic signaling (e.g., beta-blockers, bronchodilators)
- Hematocrit less than 33%
- Presence of HIV or hepatitis
- Presence of cardiovascular or peripheral vascular disease
- Presence of neuropathy, retinopathy, or nephropathy
- Any other disease or condition that could affect insulin-induced hypoglycemia responses or make participation unsafe as determined by study doctors
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Cincinnati
Cincinnati, Ohio, United States, 45267-0547
Actively Recruiting
Research Team
J
Jason Winnick, PhD
CONTACT
A
Alyssa Randolph
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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