Studying How Fasting Affects Hormonal Responses to Low Blood Sugar in Adults with Type 1 Diabetes

What this Trial Is About

Researchers are investigating how fasting affects the bodys hormonal and liver responses to insulin-induced low blood sugar hypoglycemia in people with type 1 diabetes T1D. This condition is challenging because patients often overestimate their insulin needs, leading to dangerous low blood sugar episodes. The study aims to better understand how fasting might change the bodys natural defenses against these episodes, which are weakened in T1D. Participants will take part in two separate trials one where they eat a normal breakfast and lunch before a controlled insulin-induced hypoglycemia test, and another where they remain fasted before the test. This comparison will show how fasting versus eating influences hormonal responses and liver glucose production during low blood sugar. During the study visits, participants will undergo insulin-induced hypoglycemia while researchers measure hormones like glucagon and epinephrine, liver glucose production, and glucose infusion rates over about 2.5 hours. These tests will help assess how the body counters low blood sugar under different eating conditions. The entire study includes careful monitoring to ensure safety and accurate measurement of these responses.

Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes