Actively Recruiting
Effect of Fasting Recommendations Among Patients Using GLP-1 Receptor Agonists
Led by St Vincent's Hospital Melbourne · Updated on 2026-05-11
154
Participants Needed
2
Research Sites
84 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this randomised controlled trial is to determine the effect of a 24-hour clear liquid diet compared to standard fasting guidelines on the proportion of participants who present with increased residual gastric contents during their study visit. It also aims to determine the effect of a 24-hour clear liquid diet compared to standard fasting guidelines on: * Solid content or thick fluids * Patient-reported outcome measures (PROMs), including thirst, hunger, nausea, fatigue, and anxiety. * Compliance measures, including adherence with the intervention, time since last oral intake of solid foods, and time since last oral intake of clear liquids. We will enrol adults who are currently using any once-weekly glucagon-like peptide-1 receptor agonist (GLP-1RA) medication. Participants will be allocated in a 1:1 ratio to follow a 24-hour clear liquid diet or standard fasting guidelines prior to attending a study visit where participants will undergo a blinded gastric ultrasound assessment.
CONDITIONS
Official Title
Effect of Fasting Recommendations Among Patients Using GLP-1 Receptor Agonists
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older at enrollment
- Regular use of any once-weekly GLP-1 receptor agonist medication for at least one month before randomization
- Willingness to follow ASA and ANZCA standard preoperative fasting guidelines if assigned to that group
- Willingness to follow a 24-hour clear liquid diet with no solids and clear liquids up to 2 hours before the trial visit if assigned to that group
- Signed and dated informed consent form as required by the study ethics committee
You will not qualify if you...
- Recent gastrointestinal bleeding within 1 month before enrollment
- History of lower esophageal or gastric surgery
- Known abnormal upper gastrointestinal anatomy such as hiatus hernia or gastric tumors
- Previously diagnosed with significant gastric emptying problems like gastroparesis
- Current use of insulin
- Unable to lie on the right side needed for gastric ultrasound
- Difficulty understanding study materials due to primary language other than English
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Melbourne Gastro Oesophageal Surgery (MGOS)
Melbourne, Victoria, Australia, 3002
Actively Recruiting
2
St Vincent's Hospital Melbourne
Melbourne, Victoria, Australia, 3065
Actively Recruiting
Research Team
P
Prof Michelle Dowsey, BHealthSci(Nursing), MEpi, PhD
CONTACT
J
Jasmin Elkin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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