Actively Recruiting
Effect of Fluoride Varnish Formulation on the Management of Dentin Hypersensitivity
Led by University of Concepcion, Chile · Updated on 2025-12-18
92
Participants Needed
1
Research Sites
29 weeks
Total Duration
On this page
Sponsors
U
University of Concepcion, Chile
Lead Sponsor
S
Solventum
Collaborating Sponsor
AI-Summary
What this Trial Is About
This randomized controlled clinical trial aims to determine whether different fluoride varnish formulations reduce dentin hypersensitivity (DH) in young adults diagnosed with DH. The primary purpose of this study is to evaluate the clinical effectiveness of two commercially available fluoride varnishes. The main questions this study aims to answer are: * Does Clinpro Clear® (aqueous base, 9,500 ppm NaF) lead to a greater reduction in dentin hypersensitivity compared with Duraphat® (rosin/resin base, 22,600 ppm NaF)? * Do these varnish formulations improve oral health-related quality of life and patient satisfaction? Researchers will compare a single application of Duraphat® with a single application of Clinpro Clear® to assess differences in hypersensitivity reduction, quality-of-life outcomes, and patient satisfaction. Participants will: * Receive one application of either Duraphat® or Clinpro Clear® under standardized clinical conditions. * Complete baseline and post-treatment evaluations, including: * Dentin hypersensitivity intensity using a visual analogue scale (VAS) * Air-blast response using the Schiff scale * Oral health-related quality of life using the OHIP-14 * Patient satisfaction using the CSAT survey
CONDITIONS
Official Title
Effect of Fluoride Varnish Formulation on the Management of Dentin Hypersensitivity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 40 years
- No systemic diseases with oral effects or requiring medications with antisialagogue effects
- Fully dentate except for third molars or teeth removed for orthodontic reasons
- No periodontal disease or stable periodontal condition
- At least one cervical lesion with Schiff sensitivity score 61
- No prior treatment or restorative procedures on target lesions, including no topical fluoride in last 6 months
You will not qualify if you...
- Long-term use of NSAIDs or other analgesic/anti-inflammatory medications
- Allergy to milk proteins
- Allergy to organic resins or pine-derived substances
- Pregnant or breastfeeding
- Fixed orthodontic appliances in place
AI-Screening
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Trial Site Locations
Total: 1 location
1
Clinica de Rehabilitación Avanzada e Implantologia (CRAI)
Concepción, Biobio, Chile, 4070420
Actively Recruiting
Research Team
F
Fernando Zurita, DDS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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