Enamel Fluoride Reactivity of Professional Fluoride Products Is Not Correlated With Their Total Fluoride Content.
Livia Maria Andaló Tenuta, Letícia Cabrera Capalbo, Elaine Yamada Yoshino
https://pubmed.ncbi.nlm.nih.gov/40533917/Actively Recruiting
Led by University of Concepcion, Chile · Updated on 2026-06-02
92
Participants Needed
1
Research Sites
4 weeks
Total Duration
This trial evaluates the effect of two different fluoride varnish formulations on dentin hypersensitivity DH in young adults diagnosed with this condition. Researchers aim to determine if Clinpro Clear4 aqueous base, 9,500 ppm NaF reduces DH more than Duraphat4 rosinresin base, 22,600 ppm NaF, and whether these treatments improve oral health-related quality of life and patient satisfaction. The study is a randomized controlled clinical trial comparing these two commercially available varnishes. Participants will receive a single application of either Duraphat4 or Clinpro Clear4 under standardized conditions. For Duraphat4, the tooth surface is cleaned, and a thin film is applied with a cotton applicator patients keep lip retractors in place for 15 minutes and avoid brushing or hard foods for 4 hours. For Clinpro Clear4, the tooth is cleaned and dried, varnish is applied with a brush to cover the sensitive area, and patients also keep lip retractors for 15 minutes without disturbing the varnish. During the study, participants will complete baseline and follow-up assessments at 7 and 28 days after application. These include measuring dentin hypersensitivity intensity using a visual analogue scale and Schiff scale, evaluating oral health-related quality of life with the OHIP-14 questionnaire, and assessing patient satisfaction using the CSAT survey. The study runs from baseline through 28 days post-treatment with careful monitoring of outcomes and participant experiences.
CONDITIONS
Effect of Fluoride Varnish Formulation on the Management of Dentin Hypersensitivity
F
Fernando Zurita, DDS
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University of Concepcion, Chile
Lead Sponsor
Solventum
Collaborating Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single application visit
Participants receive fluoride varnish applied to the hypersensitive tooth area. The tooth surface will be cleaned and dried, then the varnish will be applied using a brush or cotton applicator. Participants remain seated with lip retractors in place for 15 minutes and will be advised to avoid brushing teeth or hard foods for at least 4 hours after application.
1 visit (in-person)
Duration - 28 days
Participants are assessed for changes in dentin hypersensitivity and oral health-related quality of life after fluoride varnish application.
2 visits (at 7 and 28 days post-application)
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Livia Maria Andaló Tenuta, Letícia Cabrera Capalbo, Elaine Yamada Yoshino
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https://pubmed.ncbi.nlm.nih.gov/16827940/University of Concepcion, Chile
Lead Sponsor
Solventum
Collaborating Sponsor