Actively Recruiting
Effect of Full-House ESS With Nasopharyngeal Lymphoid Tissue Ablation on Nasal Polyps
Led by Tongji Hospital · Updated on 2025-11-24
32
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is designed to evaluate whether the addition of nasopharyngeal lymphoid tissue ablation to full-house endoscopic sinus surgery (ESS) provides superior control of nasal mucosa inflammation compared to full-house ESS alone in patients with nasal polyps. Thirty-two adult participants will be randomly assigned to undergo either full-house ESS only or full-house ESS combined with nasopharyngeal lymphoid tissue ablation. The primary outcome will be assessed through changes in inflammatory cell profiles at 1, 3, and 6 months postoperatively. Secondary outcomes include inflammatory cytokine levels, symptom scores, endoscopic findings, polyp recurrence rates, and safety measures.
CONDITIONS
Official Title
Effect of Full-House ESS With Nasopharyngeal Lymphoid Tissue Ablation on Nasal Polyps
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18-65 years
- Diagnosed with chronic rhinosinusitis with nasal polyps according to EPOS criteria
- Blood eosinophil count greater than 0.3 × 10⁹/L
You will not qualify if you...
- Pregnant or lactating women
- Cystic fibrosis
- Primary ciliary dyskinesia
- Fungal ball rhinosinusitis
- Systemic vasculitis or granulomatous disease
- Malignancy
- Immunodeficiency
- Upper respiratory tract infection within the past 4 weeks
- Clinically significant metabolic, cardiovascular, immune, neurologic, hematologic, gastrointestinal, cerebrovascular, or respiratory disorders that could interfere with outcome assessment or patient safety
- Currently participating in another clinical trial or participated in one within the past 30 days
- Staff directly involved in this study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
Wuhan, Hubei, China, 430030
Actively Recruiting
Research Team
Y
Yin Yao
CONTACT
X
Xing-Liang Wu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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