Comparing Full-House Endoscopic Sinus Surgery With and Without Nasopharyngeal Lymphoid Tissue Removal in Adults With Nasal Polyps to Reduce Inflammation

What this Trial Is About

Researchers are investigating whether adding nasopharyngeal lymphoid tissue ablation to full-house endoscopic sinus surgery ESS improves control of nasal mucosa inflammation in adults with nasal polyps. This study will compare the combined procedure to full-house ESS alone in patients diagnosed with chronic rhinosinusitis with nasal polyps CRSwNP. The goal is to understand if the additional ablation can better reduce inflammation and polyp recurrence. Participants will be randomly assigned to one of two groups one receiving full-house ESS alone and the other receiving full-house ESS combined with nasopharyngeal lymphoid tissue ablation. The ablation procedure involves decongesting the nasal mucosa, using a small catheter to elevate the soft palate, and endoscopically removing the nasopharyngeal lymphoid tissue with a plasma scalpel. The full-house ESS includes removal of nasal polyps, a full ethmoidectomy, sphenoidotomy, and frontal sinusotomy, preserving normal mucosa when possible. Participants will be followed for inflammation and recovery at baseline, 1, 3, and 6 months after surgery. Researchers will assess inflammatory cells, cytokine levels, symptom scores, nasal endoscopy findings, polyp recurrence, medication use, and complications. Polyp recurrence and reoperation rates will be monitored for up to 24 months. Safety and symptom changes will be carefully recorded throughout the study duration.

Effect of Full-House ESS With Nasopharyngeal Lymphoid Tissue Ablation on Nasal Polyps