Actively Recruiting

Age: 4Years - 18Years
All Genders
NCT05649930

Effect of Functional Power Training on Calf Muscle Length and Strength in Children With Spastic Paresis

Led by Amsterdam UMC, location VUmc · Updated on 2025-01-08

23

Participants Needed

1

Research Sites

171 weeks

Total Duration

On this page

Sponsors

A

Amsterdam UMC, location VUmc

Lead Sponsor

R

Reade Rheumatology Research Institute

Collaborating Sponsor

AI-Summary

What this Trial Is About

Spastic paresis (SP) is a common motor condition in children and is often caused by cerebral palsy. Skeletal muscles develop differently in children with SP due to brain damage in early development; muscle strength and muscle length are reduced compared to typically developing (TD) children. Especially, the calf muscles are affected, which particularly affects their ability to walk and to run, hindering participation in society. There are several treatments aimed to increase the range of motion of the joint by lengthening the muscle, for example botulinum toxin injections. However, these treatments can have a weakening effect on the muscle due to deconditioning from immobilization and due to paralysis. In rehabilitation centers in the Netherlands functional power training (MegaPower) is offered to children with SP who want to walk and run better. It has been shown that this training improves calf muscle strength and performance during functional walking tests. However, the effect of MegaPower training on muscle morphology (i.a. muscle volume and length) is still unknown. Therefore, the aim of this study is to assess the effect of MegaPower training on the muscle morphology of the medial gastrocnemius in children with SP using 3D ultrasonography. It is expected that MegaPower training results in an increase of muscle volume as well as elongation of the muscle belly. Muscle volume could increase due to hypertrophy of the muscle fibers induced by the training, which could elongate the muscle belly length due to the pennate structure of the medial gastrocnemius. A double-baseline design will be applied for this study with three different measurement times (T0-T1-T2) to compare the training period (12 weeks) with a period (12 weeks) of usual care.

CONDITIONS

Official Title

Effect of Functional Power Training on Calf Muscle Length and Strength in Children With Spastic Paresis

Who Can Participate

Age: 4Years - 18Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Children classified as Gross Motor Function Classification System levels I to III
  • Able to lie on their stomach for at least one minute
  • Able to follow instructions
Not Eligible

You will not qualify if you...

  • Received casting within six months prior to study
  • Received botulinum toxin type-A injections within six months prior to study
  • Received orthopedic surgery within six months prior to study

AI-Screening

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Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Reade

Amsterdam, Netherlands, 1056 AB

Actively Recruiting

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Research Team

M

Marjolein M van der Krogt, Dr.

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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