Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery-2018.
L Evered, B Silbert, D S Knopman...
https://pubmed.ncbi.nlm.nih.gov/30325806Actively Recruiting
Age: 40Years - 80Years
All Genders
ID06186089
Effects of Total Gastrectomy or Double-Tract Reconstruction on Gut Microbiome and Cognitive Function in Patients With Proximal Gastric Cancer
Led by Jiangjiang Bi · Updated on 2024-04-11
45
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating perioperative neurocognitive disorders, a common complication after surgery in elderly patients, especially those with gastrointestinal tumors like proximal gastric cancer. This study aims to understand how different surgical procedures, total gastrectomy and double-tract reconstruction, affect gut microbiota and postoperative cognitive function. The role of gastric acid in shaping gut bacteria and its link to cognitive health is a key focus. The study compares patients undergoing total gastrectomy, who will take probiotics daily for three months after surgery, with those receiving double-tract reconstruction. Researchers will analyze gut microbiota differences using 16S rRNA gene sequencing and metabonomics technology. Cognitive function will be assessed using the Mini-Mental State Examination and Montreal Cognitive Assessment scales at multiple time points: before surgery, and 1 day, 7 days, 3 months, and 12 months after surgery. Participants will have their cognitive function and gut microbiota monitored before and after surgery, along with inflammatory markers measured before, 30 minutes, and 24 hours after surgery. The study involves assessments over one year to track changes and effects of the surgical methods on brain function and gut bacteria. This ongoing evaluation aims to better understand how surgery impacts recovery and cognition in proximal gastric cancer patients.
CONDITIONS
Brief Title
Effect of Gastrectomy on Gut Microbiome and Cognitive Function
Who Can Participate
Age: 40Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of proximal gastric cancer with planned gastrectomy
- American Society of Anesthesiologists (ASA) classification I-III
- Age between 40 and 80 years
- Conscious during the perioperative period
You will not qualify if you...
- Central nervous system or psychological disorders
- Chronic use of sedatives or antidepressants within the last year
- Parkinson's disease
- Severe immunosuppression
- Severe hearing or vision impairment
- Drug dependence or alcoholism
- Inability to communicate with a physician
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Surgery and Immediate Post-operative Care
Duration - 1 day
Participants undergo total gastrectomy or double-tract reconstruction surgery. Immediate post-operative care includes monitoring inflammatory factors shortly before and after surgery.
1 surgery day visit and monitoring at preoperation, 30 minutes and 24 hours post-surgery
Treatment
Duration - 3 months
Participants undergoing total gastrectomy take probiotics once daily for 3 months after surgery.
Daily probiotic intake with regular check-ins
Post-operative Follow-up
Duration - 12 months
Participants have their cognitive function and gut microbiota composition assessed at multiple time points after surgery to monitor recovery and treatment effects.
Visits 1 day before surgery; 1 day, 7 days, 3 months, and 12 months after surgery
Trial Site Locations
Total: 1 location
1
Tongji Hospital
Wuhan, Hubei, China, 430030
Actively Recruiting
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Research Team
J
Jiangjiang Bi, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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Agata Mulak, Bruno Bonaz
https://pubmed.ncbi.nlm.nih.gov/26457021Contribution of preoperative gut microbiota in postoperative neurocognitive dysfunction in elderly patients undergoing orthopedic surgery.
Jiangjiang Bi, Yifan Xu, Shiyong Li...
https://pubmed.ncbi.nlm.nih.gov/36875700Abnormal gut microbiota composition contributes to cognitive dysfunction in SAMP8 mice.
Gaofeng Zhan, Ning Yang, Shan Li...
https://pubmed.ncbi.nlm.nih.gov/29886457Gastrectomy impact on the gut microbiome in patients with gastric cancer: A comprehensive review.
Vaidota Maksimaityte, Augustinas Bausys, Marius Kryzauskas...
https://pubmed.ncbi.nlm.nih.gov/34354801Sleeve gastrectomy drives persistent shifts in the gut microbiome.
Cyrus Jahansouz, Christopher Staley, David A Bernlohr...
https://pubmed.ncbi.nlm.nih.gov/28279578Influence of gastrectomy for gastric cancer treatment on faecal microbiome and metabolome profiles.
Pande Putu Erawijantari, Sayaka Mizutani, Hirotsugu Shiroma...
https://pubmed.ncbi.nlm.nih.gov/31953253Differences in Alimentary Glucose Absorption and Intestinal Disposal of Blood Glucose After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy.
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https://pubmed.ncbi.nlm.nih.gov/26481855Effect of nutrition on neurodegenerative diseases. A systematic review.
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