Predictors, prevention, and management of postoperative pain associated with nonsurgical root canal treatment: A systematic review.
Mothanna K AlRahabi
https://pubmed.ncbi.nlm.nih.gov/31435267Actively Recruiting
Phase Not Applicable
Age: 18Years - 65Years
All Genders
Healthy Volunteers
ID06937853
Effect of Genetic Differences on Response to Preoperative NSAIDs for Postoperative Pain After Root Canal Treatment A Randomized Study Comparing Ibuprofen, Diclofenac Sodium, and Placebo
Led by Ataturk University · Updated on 2025-07-11
200
Participants Needed
1
Research Sites
64 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how genetic differences affect the response to preoperative non-steroidal anti-inflammatory drugs (NSAIDs) in managing pain after root canal treatment. The study focuses on patients experiencing postoperative pain following endodontic procedures and aims to personalize pain management based on individual gene variations. Participants will receive a single oral dose of one of three treatments before their root canal therapy: 600 mg of ibuprofen, 100 mg of diclofenac sodium, or a placebo that looks like the active drugs. These treatments are given to assess their effectiveness in reducing pain after the procedure. During the study, participants' pain levels will be measured seven days after treatment. Genetic testing will be done to explore links between gene differences and pain relief. The study includes monitoring pain intensity and evaluating how genetics may influence responses to the medications, helping to improve personalized pain control in dental care.
CONDITIONS
Official Title
Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management
Who Can Participate
Age: 18Years - 65Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Patients aged between 18 and 65 years
- Vital mandibular molar teeth diagnosed with symptomatic apical periodontitis
- ASA physical status classification I or II
- Preoperative VAS pain score greater than 50
- No known genetic disorders (e.g., Down syndrome, congenital insensitivity to pain)
You will not qualify if you...
- Patients classified as ASA III or higher
- Pregnant women or those suspected of being pregnant
- Presence of root canal curvature greater than 25° (Schilder classification)
- Patients with generalized periodontitis
- Presence of periodontal pockets deeper than 3 mm in the affected tooth
- History of systemic disease or known allergies
- Patients with diagnosed psychiatric or psychological disorders
- Presence of swelling, sinus tract, or preoperative tenderness on palpation
- Patients with bruxism
- Presence of resorption in the affected tooth
- Use of analgesic or anti-inflammatory drugs within 12 hours prior to the procedure
- Teeth with root fractures, ankylosis, or pathological mobility
AI-Screening
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1
2
3
Trial Site Locations
Total: 1 location
1
Ataturk University, Faculty of Dentistry, Department of Endodontics
Erzurum, Erzurum, Turkey (Türkiye), 25100
Actively Recruiting
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Research Team
E
Ertugrul Karatas, Prof. Dr.
M
Melike Kahramanlar, Postgraduate Student
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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