Actively Recruiting
Effect of Geriatric Intervention in Frail Patients with Gastric, Biliary, and Pancreatic Cancer Receiving Palliative Chemotherapy
Led by Chang Gung Memorial Hospital · Updated on 2025-02-13
138
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Gastric, biliary, and pancreatic cancers are common gastrointestinal cancers in Taiwan, often diagnosed at advanced stages when surgery is not an option. Palliative chemotherapy is a standard treatment to help extend survival and improve quality of life. However, elderly patients often receive less or lower doses of chemotherapy due to concerns about age, other health issues, and treatment side effects. This trial focuses on selecting elderly patients appropriately for chemotherapy by assessing frailty, which affects treatment tolerance and outcomes. Participants will undergo a frailty assessment within seven days before starting their first cycle of palliative chemotherapy. Based on this assessment, patients identified as frail (with impairments in at least two areas) will receive tailored geriatric interventions addressing functional status, nutrition, comorbidities, mobility, mood, cognition, medication use, and social support. Non-frail patients will receive standard care without additional interventions. The study compares chemotherapy tolerance, treatment-related toxicity, and quality of life between frail and non-frail groups. During the study, patients will be monitored for chemotherapy completion rates over three months, and adverse events will be assessed using standard criteria. Quality of life will be measured before and after treatment using validated questionnaires. Researchers will also observe treatment-related toxicity and the impact of geriatric interventions on these outcomes. Participation lasts at least three months, with evaluations focused on chemotherapy tolerance and patient well-being.
CONDITIONS
Brief Title
Effect of Geriatric Intervention in Frail Patients with Gastric, Biliary, and Pancreatic Cancer Receiving Palliative Chemotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 65 years or older with metastatic or unresectable gastric, biliary, or pancreatic cancer
- Signed informed consent form
- Estimated survival period of more than 3 months
- Conscious and able to communicate verbally or in writing, willing to cooperate with invasive procedures
You will not qualify if you...
- Cognitive impairment or inability to cooperate with interventional procedures as determined by a clinical physician
- Receiving concurrent anticancer treatments such as radiation or surgery
- Having multiple types of cancer requiring simultaneous treatment
- Previously participated in this study during an earlier chemotherapy regimen
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - Up to 7 days before starting chemotherapy
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 3 months
Participants receive palliative chemotherapy. Frail participants receive additional geriatric interventions based on their specific impairments in areas such as functional status, nutrition, mobility, mood, and cognition.
Visits aligned with chemotherapy cycles over 3 months
Duration - After completion of 3 months of chemotherapy treatment
Participants are assessed for chemotherapy completion, adverse events, treatment-related toxicity, and quality of life after treatment.
1 follow-up visit
Trial Site Locations
Total: 1 location
1
Chang Gung Memorial Hospital
Taoyuan, Taiwan, Taiwan, 330
Actively Recruiting
Research Team
W
Wen-Chi Chou, M.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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