Actively Recruiting
Effect of Giving Reduced Fluid in Children After Trauma
Led by Columbia University · Updated on 2026-05-07
250
Participants Needed
4
Research Sites
470 weeks
Total Duration
On this page
Sponsors
C
Columbia University
Lead Sponsor
N
Northwell Health
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is designed to help decide how much intravenous (IV) fluid should be given to pediatric trauma patients. No standard currently exists for managing fluids in critically ill pediatric trauma patients, and many fluid strategies are now in practice. For decades, trauma patients got high volumes of IV fluid. Recent studies in adults show that patients actually do better by giving less fluid. The investigators do not know if this is true in children and this study is designed to answer that question and provide guidelines for IV fluid management in children after trauma.
CONDITIONS
Official Title
Effect of Giving Reduced Fluid in Children After Trauma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Trauma patients older than 6 months and younger than 15 years admitted to the pediatric intensive care unit (PICU)
- Patients admitted to the PICU directly from the Emergency Department (ED)
- Patients admitted to the PICU from the operating room (OR)
- Patients transferred to PICU from outside facility ED (need to have been in ED 12 hours or less)
You will not qualify if you...
- Patients transferred to PICU from outside PICU or inpatient floor
- Patients transferred to PICU from outside facility ED if >12 hours
- Patients expected to be discharged from the PICU within 24 hours
- Patient with congenital heart disease as defined by a congenital cardiac defect requiring surgery or medication
- Patient with diagnosis of chronic cardiac condition (e.g. hypertension, cardiac arrhythmia)
- Patients with chronic kidney disease as defined by an abnormality of kidney structure or function, present for more than 3 months, with implications to health
- Post-operative transplant, cardiac, and neurosurgical patients
- Patients with traumatic brain injury
- Patients with any disease that may affect baseline blood pressure and heart rate (endocrine disorders, certain genetic disorders, mitochondrial diseases)
- Hypotension requiring vasopressor therapy
- If massive transfusion protocol initiated
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
John R. Oishei Children's Hospital of Buffalo
Buffalo, New York, United States, 14203
Not Yet Recruiting
2
Columbia University Irving Medical Center NewYork-Presbyterian Morgan Stanley Children's Hospital
New York, New York, United States, 10032
Actively Recruiting
3
University of Rochester, Golisano Children's Hospital
Rochester, New York, United States, 14642
Actively Recruiting
4
Le Bonheur Children's Hospital
Memphis, Tennessee, United States, 38103
Actively Recruiting
Research Team
V
Vincent P Duron, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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