Actively Recruiting
Effect of a GnRH Analog on Hepatic Steatosis
Led by Aristotle University Of Thessaloniki · Updated on 2026-02-03
62
Participants Needed
2
Research Sites
148 weeks
Total Duration
On this page
Sponsors
A
Aristotle University Of Thessaloniki
Lead Sponsor
4
424 General Military Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Menopause increases the risk of metabolic dysfunction-associated steatotic liver disease (MASLD), possibly owing to the abrupt lack of estrogen. Gonadotropin-releasing hormone (GnRH) treatment in endometriosis is regarded as a model of pharmaceutical menopause. Thus, the effect of goserelin acetate, a GnRH analog that results in transient menopause, on hepatic steatosis and fibrosis will be evaluated in this study.
CONDITIONS
Official Title
Effect of a GnRH Analog on Hepatic Steatosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women of reproductive age
- Diagnosed with endometriosis confirmed by surgery and biopsy
- Contraindicated for contraceptive use or declined contraceptives due to personal preference
- Provided written informed consent to participate
You will not qualify if you...
- Consuming more than 10 grams of alcohol daily
- History of other chronic liver diseases such as viral hepatitis, autoimmune hepatitis, or drug-induced liver injury
- Presence of liver cirrhosis
- Any malignancy
- Chronic kidney disease
- Uncontrolled thyroid disorders
- Severe sex hormone disorders like congenital adrenal hyperplasia, Down syndrome, or Turner syndrome
- Use of medications associated with liver injury or improvement of liver fat within 12 months before the study
- Use of any GnRH agonist or antagonist within 12 months before baseline
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
1st Department of Obstetrics and Gynecology, School of Medicine, Aristotle University of Thessaloniki
Thessaloniki, Greece, 56403
Actively Recruiting
2
424 General Military Hospital
Thessaloniki, Greece, 56429
Actively Recruiting
Research Team
S
Stergios A Polyzos, MD, PhD
CONTACT
D
Dimitrios A Anastasilakis, MD, PhDc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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