Effect of Goal-directed Analgesia and Sedation Using EEG Derived QCON/qNOX in ICU Patients Undergoing Mechanical Ventilation: a Randomized Controlled Trial

What this Trial Is About

Sedation and pain relief are key in caring for critically ill patients who need mechanical ventilation. Excessive sedation can prolong ventilation time and ICU stay, and increase risks like low blood pressure, blood clots, and hospital-acquired pneumonia. This research evaluates the use of the Conox4 system in ICU patients to better monitor sedation levels using EEG signals, aiming to improve sedation management compared to standard clinical methods. Participants will be randomly assigned to two groups: one where sedation is adjusted using EEG-based indexes (qCON/qNOX) from the Conox device, and another where sedation follows the usual clinical scales and standard care. This trial compares these two approaches in patients expected to need mechanical ventilation for more than 48 hours. Throughout their ICU stay, patients will be closely monitored with EEG or standard clinical assessments to guide sedation. Researchers will track ventilator-free days by day 28 to evaluate outcomes. The study includes adults aged 18 to 90 who have been in the ICU less than 24 hours and are already sedated. Safety and effectiveness of sedation management will be observed during their treatment period.

Effect of Goal-directed Analgesia and Sedation Using EEG Derived QCON/qNOX in ICU Patients