Actively Recruiting
the Effect of High Caloric Oral Nutritional Supplements on Growth and Development of Malnourished Children
Led by Children's Hospital of Chongqing Medical University · Updated on 2026-03-18
200
Participants Needed
13
Research Sites
90 weeks
Total Duration
On this page
Sponsors
C
Children's Hospital of Chongqing Medical University
Lead Sponsor
A
Anhui Provincial Children's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate the effect of high caloric oral nutritional supplements on body proportion, weight, linear growth pattern, neuropsychological development level and related health aspects (gut health, immune function, quality of life, etc.) in participants aged 1 to 3 years who are malnourished (underweight and wasting),as well as to evaluate the safety of applying high caloric oral nutritional supplements. Participants will receive nutritional education and daily high caloric oral nutritional supplements(experimental group),or will receive nutritional education and dietary instruction(control group).This study may provide data to support the development of clinical intervention strategies for malnourished Chinese children.
CONDITIONS
Official Title
the Effect of High Caloric Oral Nutritional Supplements on Growth and Development of Malnourished Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 1 to 3 years
- BMI for Age Z-score less than -2
- Height-for-age Z-score less than -2
- Total daily energy intake less than 75% of recommended nutrient intake
- Child's guardian willing to participate and sign an informed consent form
You will not qualify if you...
- Chronic or severe infectious diseases such as chronic hepatitis, HIV, or tuberculosis
- Congenital or genetic diseases affecting growth and development (e.g., congenital heart disease, Down's syndrome, infantile anorexia nervosa), malignancies, or current use of drugs like diuretics, appetite stimulants, steroids, or growth hormones
- Severe gastrointestinal disorders such as celiac disease, short bowel syndrome, or inflammatory bowel disease
- Acute or chronic respiratory or digestive infections within 2 weeks before enrollment
- Allergy or contraindication to ingredients in the high-energy nutritional formula
- Use of high-energy enteral nutrition preparations within the last 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
Anhui Provincial Children's Hospital
Hefei, Anhui, China, 230001
Actively Recruiting
2
Children's Hospital of The Capital Institute of Pediatrics
Beijing, Beijing Municipality, China, 100020
Actively Recruiting
3
The First Hospital of Jilin University
Jilin, Changchun, China
Actively Recruiting
4
Growth, Development and Mental health of Children and Adolescence Center
Chongqing, Chongqing Municipality, China, 400014
Actively Recruiting
5
Guangzhou Women and Children's Medical Center
Guangzhou, Guangdong, China, 510200
Actively Recruiting
6
Guiyang Maternity and Child Health Care Hospital
Guiyang, Guizhou, China, 550003
Actively Recruiting
7
Hunan Children's Hospital
Changsha, Hunan, China, 410007
Actively Recruiting
8
Nanjing Maternity and Child Health Care Hospital
Nanjing, Jiangsu, China, 210004
Actively Recruiting
9
Jiangxi Maternal and Child Health Hospital
Nanchang, Jiangxi, China, 330006
Actively Recruiting
10
Baoji Maternity and Child Healthcare Hospital
Baoji, Shanxi, China, 721000
Actively Recruiting
11
Xianyang Children's Hospital
Xianyang, Shanxi, China, 712000
Actively Recruiting
12
Chengdu Women's and Children's Central Hospital，School of Medicine，University of Electronic Science and Technology of China
Chengdu, Sichuan, China, 610091
Actively Recruiting
13
Kunming Children's Hospital
Kunming, Yunnan, China, 650000
Actively Recruiting
Research Team
L
Li Chen, doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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