Actively Recruiting
Effect of High Dose Insulin on Infectious Complications Following Major Surgery
Led by McGill University Health Centre/Research Institute of the McGill University Health Centre · Updated on 2025-05-08
460
Participants Needed
3
Research Sites
373 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Despite improvements in surgical techniques and perioperative care, the high incidence of postoperative surgical site infections remains a major problem in patients undergoing major abdominal surgery (liver, pancreatic and colorectal surgery). Using the hyperinsulinemic-normoglycemic clamp technique, i.e. continuous infusion of insulin combined with dextrose titrated to "clamp" blood glucose between 4 and 6 mmol/L, we successfully established and preserved normoglycemia during the perioperative period. Our objective of this study is to determine if the maintenance of perioperative normoglycemia by a hyperinsulinemic normoglycemic clamp reduces the rates of incisional and space/ surgical site infections following abdominal surgery (liver, pancreatic and colorectal surgery).
CONDITIONS
Official Title
Effect of High Dose Insulin on Infectious Complications Following Major Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Over 18 years old
- Scheduled for elective liver, pancreatic, or colorectal surgery
- Ability to give informed consent
You will not qualify if you...
- Inability to give consent
- Current wound infection
- Previous surgery at the same site within the preceding 30 days
- Allergy to insulin
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Royal Victoria Hospital, McGill University Health Centre
Montreal, Quebec, Canada, H3A 1A1
Actively Recruiting
2
Royal Victoria Hospital
Montreal, Quebec, Canada, H3A1A1
Not Yet Recruiting
3
Hospital Clinico Universidad de Chile
Independencia, Santiago Metropolitan, Chile, 8380456
Not Yet Recruiting
Research Team
R
Ralph Lattermann, MD PhD
CONTACT
T
Thomas Schricker, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
2
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