Actively Recruiting
Effect of HIgh-flow Therapy in Long-term Oxygen Therapy
Led by Skane University Hospital · Updated on 2025-05-21
310
Participants Needed
2
Research Sites
233 weeks
Total Duration
On this page
Sponsors
S
Skane University Hospital
Lead Sponsor
U
Uppsala University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a registry-based, randomized, controlled clinical trial of the effect of added high-flow oxygen therapy (using the device Lumis HFT) during one year in people with long-term oxygen therapy (LTOT) for chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD).
CONDITIONS
Official Title
Effect of HIgh-flow Therapy in Long-term Oxygen Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 40 years or older
- Ongoing long-term oxygen therapy prescribed for at least 15 hours per day and for at least 28 days registered in Swedevox
- Chronic obstructive pulmonary disease or interstitial lung disease as the main reason for long-term oxygen therapy
- Use of an oxygen concentrator as a stationary oxygen source at home, including nighttime use
- Body mass index (BMI) less than 35 kg/m2
You will not qualify if you...
- Current or previous treatment with home high-flow oxygen therapy
- Current treatment with home mechanical ventilation
- Current treatment with home continuous positive airway pressure (CPAP)
- Hospitalization during the last 2 weeks
- Current smoking or contact with open flames
- Self-reported use of long-term oxygen therapy less than 15 hours per day
- Partial pressure of carbon dioxide (PaCO2) breathing air at rest greater than 8 kPa
- Strong suspicion of obstructive sleep apnea or obesity-related hypoventilation syndrome as judged by study staff
- Inability to participate in study procedures as judged by study staff
- Not eligible for continuing long-term oxygen therapy for other reasons as judged by study staff
- Expected survival less than 3 months as judged by study staff
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Research Unit, Blekinge University of Technology
Karlskrona, Blekinge County, Sweden, 37185
Actively Recruiting
2
Department of Heart, Lung and Clinical Physiology, Örebro University Hospital
Örebro, Sweden, 70185
Actively Recruiting
Research Team
M
Magnus Ekström, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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