Actively Recruiting
Effect of High Intensity Exercise Rehabilitation on Liver Function and Insulin Sensitivity in Patients With MASLD
Led by University Ghent · Updated on 2024-06-07
92
Participants Needed
1
Research Sites
98 weeks
Total Duration
On this page
Sponsors
U
University Ghent
Lead Sponsor
U
University Hospital, Ghent
Collaborating Sponsor
AI-Summary
What this Trial Is About
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease worldwide, and is associated with obesity and the metabolic syndrome. Physical activity and lifestyle interventions are among the most recommended treatments for individuals with MASLD. In this RCT, we will evaluate the effect of combined exercise training "strength and aerobic training" versus "strength and high intensity training (HIIT)". The main outcome parameter is the severity of liver steatosis. Patients will be recruited at the fatty liver clinic of the UZ Gent.
CONDITIONS
Official Title
Effect of High Intensity Exercise Rehabilitation on Liver Function and Insulin Sensitivity in Patients With MASLD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with MASLD by ultrasound, CAP and/or biopsy
- Age between 18 and 75 years old
- No significant liver fibrosis (Fibroscan < 7.5 kPa; if between >7.5 and <10, biopsy must show no fibrosis)
You will not qualify if you...
- Other liver diseases that affect the patient's condition
- Severe cardiovascular, orthopedic, physical, or other illnesses preventing safe participation in exercise
- Pregnancy
- Use of medications directly affecting MASLD (e.g., GLP-1 analogues)
- Medication changes in the last 3 months that affect metabolic disease stability
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Ghent University Hospital
Ghent, Belgium, 9000
Actively Recruiting
Research Team
P
Patrick Calders, Prof. dr.
CONTACT
S
Sander Lefere, dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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