Evaluating the Effect of a Structured Home-based Physical Training Program for Kidney Transplant Recipients With Impaired Pre-transplant Physical Function

What this Trial Is About

Researchers are evaluating whether a home-based training program can improve physical function in adult kidney transplant recipients who have reduced physical function before transplantation. This study is a randomized clinical trial designed to assess how a structured physical training program affects frailty and physical performance one year after kidney transplantation. It aims to provide new knowledge to improve outcomes for transplant recipients and optimize donor organ use. Participants are randomly assigned to two groups: one follows a 12-week home-based training program starting four weeks after transplantation, and the other receives standard care with advice on regular exercise. The training includes two strength sessions and one cardio session each week, with additional optional activities. A physiotherapist guides participants initially, and the training group receives weekly phone follow-ups. Activity is tracked using patient logs and heart rate monitors. Throughout the study, participants undergo assessments including the 6-minute walking test and Clinical Frailty Scale at baseline and one year post-transplant. Additional tests such as hand-grip strength, sit-to-stand test, bone density, and muscle mass measurements occur at various points up to one year. The study monitors physical function, frailty, graft function, survival, quality of life, and psychological distress over the study period, which is expected to enroll patients over 2-3 years starting in early 2024.

Effect of Home-based Training Program for Kidney Transplant Recipients (HOMETRAIN-KTR)