Actively Recruiting
Effect of HPV Integration on Prognosis of Young Women With CIN2 in China
Led by Fujian Maternity and Child Health Hospital · Updated on 2024-09-19
300
Participants Needed
20
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Clinically, cervical precancerous lesion is one of the important diseases that endanger the life safety and fertility of young women. Women with histopathologically confirmed CIN2 need regular HPV, cervical cytology, and colposcopic biopsy if necessary to assess the outcome and progression of the disease. In this study, we intend to visit Fujian Maternal and Child Health Hospital, Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science \& Technology and other hospitals, including 300 CIN2 participants aged 45 and below diagnosed by histopathology, and collect the remaining cervical secretions and cervical exfoliated cell samples after clinical examination, even if you do not participate in this clinical study. In clinical diagnosis, treatment and follow-up, it is also necessary to collect the above specimens for relevant medical tests. Therefore, it is of great clinical and scientific significance to explore the role of HPV integrated detection in predicting the prognosis of young women with CIN2.
CONDITIONS
Official Title
Effect of HPV Integration on Prognosis of Young Women With CIN2 in China
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female aged 18 to 45 years who wishes to conceive
- Diagnosed with HSIL (CIN2) or HSIL (CIN2-3) by cervical tissue biopsy within the past 3 months
- No cervical surgery, physical therapy, or medication treatment received
- Lesion area under colposcopy less than 50% of total cervical area within the past 3 months
- Plans to follow-up for 12 months without treatment if disease does not progress
- Understands and agrees to participate in 12-month follow-up and signs informed consent
You will not qualify if you...
- Type III transformation zone on colposcopy within the past 3 months
- Pregnant or lactating
- History of malignant reproductive tract tumors
- History of hysterectomy, cervical surgery, or pelvic radiation therapy
- Received physical therapy to the cervix within 24 months prior to enrollment
- Has active severe immune system disease
- Long-term contraceptive use within 12 months prior to enrollment
- Vaginal medication or irrigation within 72 hours prior to sampling
- Sexual intercourse within 24 hours prior to sampling
- Treatment for genital infections, HPV, or other STDs within past month
- Used antibiotics or vaginal microecological products within past month
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 20 locations
1
Fujian Maternity and Child Health Hospital
Fuzhou, Fujian, China, 350001
Actively Recruiting
2
Fujian Medical University Union Hospital
Fuzhou, Fujian, China
Actively Recruiting
3
The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China
Actively Recruiting
4
Longyan First Hospital
Longyan, Fujian, China
Actively Recruiting
5
The Second Hospital of Longyan
Longyan, Fujian, China
Actively Recruiting
6
Ningde Municipal Hospital of Ningde Normal University
Ningde, Fujian, China, 352100
Actively Recruiting
7
The First Hospital of Putian City
Putian, Fujian, China, 351100
Actively Recruiting
8
The Affiliated Hospital of Putian University
Putian, Fujian, China
Actively Recruiting
9
Sanming Second Hospital
Sanming, Fujian, China
Actively Recruiting
10
Zhangzhou affiliated Hospital of Fujian Medical University
Zhangzhou, Fujian, China, 363000
Actively Recruiting
11
Gansu Provincial Maternal and Child Health Care Hospital
Lanzhou, Gansu, China
Actively Recruiting
12
Shenzhen Maternity and Child HealthCare Hospital
Shenzhen, Guangdong, China
Actively Recruiting
13
Guiyang maternal and child health care hospital
Guiyang, Guizhou, China
Actively Recruiting
14
Hubei Maternal and Child Health Care Hospital
Wuhan, Hubei, China
Actively Recruiting
15
Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology
Wuhan, Hubei, China
Actively Recruiting
16
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China
Actively Recruiting
17
Jiangxi maternal and Child Health Hospital
Nanchang, Jiangxi, China
Actively Recruiting
18
Shanghai First Maternity and Infant Hospital
Shanghai, Shanghai Municipality, China
Actively Recruiting
19
Northwest Women's and Children's Hospital
Xi’an, Shanxi, China
Actively Recruiting
20
The First Affiliated Hospital of Ningbo University
Ningbo, Zhejiang, China
Actively Recruiting
Research Team
B
Binhua Dong
CONTACT
P
Pengming Sun
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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