Evaluating Hyaluronic Acid Injection Effects on Inflammation and Symptoms in Adults with Knee Osteoarthritis Aged 45 to 75

What this Trial Is About

This research aims to evaluate the effects of intra-articular hyaluronic acid injection therapy on inflammation markers and symptoms in adults with knee osteoarthritis aged 45 to 75. The study compares changes in TNF-alpha and IL-1beta levels and methylation in blood and synovial fluid before and after treatment, alongside assessing pain, functional status, and quality of life. Participants are randomly assigned to either the active treatment or placebo group in a double-blind design. Participants receive either three weekly injections of hyaluronic acid or saline into the knee joint, with blood and synovial fluid samples collected before treatment and one week after the final injection. All participants follow a home exercise program. The study includes two groups one receiving the active hyaluronic acid injections and the other receiving placebo saline injections, allowing comparison of treatment effects. Throughout the study, participants undergo evaluations of inflammatory markers before and after treatment, and assessments of pain and function using validated scales at baseline, and at 1, 3, and 6 months post-treatment. Researchers monitor levels of TNF-alpha and IL-1beta and their methylation changes in biological samples to understand treatment impact. The study concludes with comprehensive follow-up to assess symptom changes and quality of life over six months.

The Effect of Hyaluronic Acid Injection on TNF-Alpha and IL-1β in Knee Osteoarthritis