Actively Recruiting
Effect of Hydroxyapatite Toothpaste and Mouthwash in Preventing White Spot Lesions During Orthodontic Treatment
Led by Heba Tahseen Almasri · Updated on 2026-01-08
75
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to evaluate the effect of hydroxyapatite-containing toothpaste and mouthwash in preventing white spot lesions in patients undergoing orthodontic treatment. Participants: 75 patients will be divided into three groups: * Group A: Participants will brush their teeth three times a day using hydroxyapatite toothpaste and rinse twice a day with a placebo mouthwash. * Group B: Participants will brush their teeth three times a day using fluoride toothpaste and rinse twice a day with hydroxyapatite mouthwash. * Group C (Control Group): Participants will brush their teeth three times a day using fluoride toothpaste and rinse twice a day with a placebo mouthwash. Patients will be followed during their orthodontic treatment to assess the development of white spot lesions. The study is safe and involves no surgical procedures or risky medications, and will be conducted under the supervision of Principal Investigator Heba Masri after obtaining ethical approval.
CONDITIONS
Official Title
Effect of Hydroxyapatite Toothpaste and Mouthwash in Preventing White Spot Lesions During Orthodontic Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients receiving comprehensive orthodontic treatment
- Complete permanent teeth up to first premolar with no extractions planned
- Good overall health
- Good oral hygiene with full-mouth plaque score less than 20%
- No bleeding on probing after 30 seconds
- Discontinuous band of plaque at gingival margin
- Normal stimulated salivary flow rate
- Normal salivary buffer capacity with final pH between 6.0 and 7.0
You will not qualify if you...
- History of previous orthodontic treatment
- Bleaching or topical fluoride treatment within last six months
- Severely rotated study teeth limiting facial surface appearance
- Visible signs of caries, fluorosis, hypocalcification, or other developmental defects
- Restorations on the front surface of study teeth
- Systemic or endocrine conditions such as cardiac pacemakers or diabetes mellitus
- Craniofacial anomalies or clefts
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Baghdad - College of Dentistry / Orthodontic Clinic
Baghdad, Iraq
Actively Recruiting
Research Team
H
Heba Tahseen Almasri, BSc, MSc (candidate)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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