Studying Hyperbaric Oxygen Therapy to Speed Recovery After Anterior Cruciate Ligament Reconstruction Surgery

What this Trial Is About

Anterior cruciate ligament ACL rupture is a common sports injury that causes significant functional problems and delays return to sport. This trial investigates the effect of hyperbaric oxygen therapy HBOT on accelerating recovery following ACL reconstruction ACLR surgery. Researchers aim to evaluate whether HBOT can improve healing speed and quality after ACLR, based on promising results from animal studies and earlier human trials involving ligament injuries. Participants receive either active HBOT or sham HBOT over a 6-week period. The active treatment involves 30 sessions 5 sessions per week of 90 minutes breathing 100% oxygen at 2 atmosphere absolute ATA with brief air breaks. The sham treatment mimics the procedure but uses normal air at low pressure to simulate the sensation of pressure without the full oxygen exposure. Both treatments use a multiplace hyperbaric chamber. During the study, participants undergo assessments including knee function questionnaires, MRI scans, ligament laxity tests, range of motion and edema measurements, pain ratings, muscle strength tests, and functional performance tests. Researchers measure changes from baseline immediately after the intervention. The trial monitors participants for up to about 6 weeks during treatment, with detailed functional and imaging evaluations to assess recovery progress. The lead sponsor is Assaf-Harofeh Medical Center.

The Effect of Hyperbaric Oxygen Therapy for Acceleration Recovery After Anterior Cruciate Ligament Reconstruction(ACLR)