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Evaluating How Hyperbaric Oxygen Therapy Affects Blood Stem Cells in Adults Aged 20 to 80
Led by Assaf-Harofeh Medical Center · Updated on 2026-04-21
60
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are studying the effects of Hyperbaric Oxygen Therapy HBOT on circulating hematopoietic stem cells HSCs in the blood. Hematopoietic stem cells are responsible for producing all blood lineages and their number and function decline with age, contributing to biological aging. This study aims to evaluate how HBOT, which has been shown to increase stem cell proliferation and mobilization, affects these circulating stem cells in patients who are candidates for HBOT. The treatment involves sessions of HBOT lasting 90 minutes each, administered five times a week for at least 40 sessions. During each session, patients breathe 100% oxygen at 2 atmospheres absolute ATA pressure with five-minute air breaks every 20 minutes. The therapy is delivered using a multiplace hyperbaric oxygen chamber at a specialized medical center. Participants will provide blood samples to measure changes in hematopoietic stem cells before and immediately after the HBOT intervention. Researchers will assess the stem cell levels using blood tests and monitor changes from baseline as the primary outcome. The study includes adults aged 20 to 80 years who are starting HBOT for other reasons and who agree to blood sample collection. The total duration and follow-up details depend on the therapy schedule and outcome measurements.
CONDITIONS
Brief Title
The Effect of Hyperbaric Oxygen Therapy on Circulating Hematopoietic Stem Cell Population
Research Team
S
Shai Efrati, Prof
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