Studying Daily Hypercapnia Treatment to Improve Breathing and Sleep Apnea in Adults with Chronic Spinal Cord Injury

What this Trial Is About

Researchers are investigating the effects of a new respiratory muscle training using daily acute intermittent hypercapnia dAIHc treatments on respiratory recovery and sleep apnea in people with chronic spinal cord injury SCI. Spinal cord injury often damages the diaphragm muscle, leading to serious breathing problems and increased risk of respiratory failure. This pilot study aims to explore an innovative therapy to improve respiratory muscle strength and reduce sleep apnea severity in Veterans and others living with SCI, addressing a critical need for better treatments. Participants will receive intermittent hypercapnia treatment five days a week for two weeks. This involves controlled exposure to elevated carbon dioxide levels designed to strengthen respiratory muscles. The study uses a controlled design to test feasibility, tolerability, and acceptability of the intervention. Both SCI patients and able-bodied individuals with obstructive sleep apnea OSA will take part to compare outcomes. The intervention aims to stimulate respiratory plasticity and improve daytime symptoms related to sleep-disordered breathing. During the study, researchers will monitor recruitment, withdrawal rates, and participant responses to treatment. They will measure minute ventilation and changes in sleep apnea severity over the two-week period. Safety and feasibility will be assessed alongside clinical endpoints to inform a larger future clinical trial. Participants will be evaluated through respiratory function tests and sleep assessments. The total study duration covers the two-week treatment and includes follow-up to observe respiratory improvements and symptom changes.

Effect of Hypercapnia Treatment on Respiratory Recovery After Spinal Cord Injury