Actively Recruiting
Effect of Hypercapnia Treatment on Respiratory Recovery After Spinal Cord Injury
Led by VA Office of Research and Development · Updated on 2026-04-02
30
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
Sponsors
V
VA Office of Research and Development
Lead Sponsor
V
VA Detroit Healthcare System
Collaborating Sponsor
AI-Summary
What this Trial Is About
It is estimated that 1,275,000 people in the United States alone live with spinal cord injury, including around 100,000 Veterans with spinal cord injury, making the V.A. the largest integrated health care system in the world for spinal cord injuries injury care. New therapies are needed to prevent the morbidities and mortalities associated with the high prevalence of respiratory disorders in Veterans with spinal cord injury. The current research project and future studies would set the base for developing innovative therapies for this disorder. This proposal addresses a new therapeutic intervention for sleep apnea in spinal cord injury. The investigators hypothesized that daily hypercapnia treatments improve respiratory symptoms and alleviate sleep apnea in patients with chronic spinal cord injury. The investigators will perform a pilot study to examine the impact of daily hypercapnia treatments for-two week durations among Veterans with spinal cord injury. The investigators believe that this novel approach to treating sleep apnea and will yield significant new knowledge that improves the health and quality of life of these patients.
CONDITIONS
Official Title
Effect of Hypercapnia Treatment on Respiratory Recovery After Spinal Cord Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients with chronic spinal cord injury or disease (more than 6 months post-injury)
- American Spinal Injury Association (ASIA) classification A-D with evidence of sleep-disordered breathing
- Able-bodied patients without spinal cord injury or disease who have obstructive sleep apnea
You will not qualify if you...
- Receiving continuous mechanical ventilation (except PAP therapy)
- Severe congestive heart failure with ejection fraction less than 35%
- Recent health events affecting sleep such as stroke, acute myocardial infarction, recent surgery, or hospitalization
- Alcohol or substance abuse with less than 90 days of sobriety
- Self-described as too ill to participate in study procedures
- Evidence of hypercapnia on spontaneous breathing (end-tidal CO2 greater than 50 mmHg)
- Unable to provide self-consent for participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
John D. Dingell VA Medical Center, Detroit, MI
Detroit, Michigan, United States, 48201-1916
Actively Recruiting
Research Team
A
Abdulghani Sankari, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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