Actively Recruiting
Effect of Hypophosphatemia on Neuro-excursion Efficiency During Mechanical Ventilator Weaning
Led by Peking Union Medical College · Updated on 2025-05-31
70
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effects of low blood phosphate levels (hypophosphatemia) on patients undergoing mechanical ventilation in the intensive care unit (ICU). This condition is common during ICU stays and has been linked to longer times on ventilators. The study aims to understand how hypophosphatemia affects diaphragm muscle function and nerve signals during the process of weaning patients off mechanical ventilation, with the goal of improving respiratory muscle strength and patient recovery. Patients eligible for the study have acute respiratory failure and have been on invasive ventilators for at least 48 hours. When patients meet criteria to begin weaning from the ventilator, they receive a diaphragm electromyography catheter to monitor muscle activity. They undergo a process called CPAP disconnection with measurements taken at multiple time points up to 30 minutes. Blood phosphate levels are monitored, and patients with low phosphate receive intravenous sodium glycerophosphate at doses adjusted to their phosphate level, while those with normal phosphate receive no special treatment. The procedure repeats 24 hours later to assess changes. Participants will be closely monitored with ventilator settings, diaphragm muscle activity, ultrasounds, and blood phosphate tests during the study. Researchers focus on measuring neural-excursion efficiency over time during the breathing trial. The study includes safety monitoring related to catheter placement and phosphate infusion. Participation involves multiple assessments during the weaning process and continues through a second evaluation after one day, helping researchers better understand phosphate's role in respiratory muscle function during ventilator weaning.
CONDITIONS
Brief Title
Effect of Hypophosphatemia on Neuro-excursion Efficiency During Mechanical Ventilator Weaning
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Acute respiratory failure requiring tracheal intubation
- Use of invasive mechanical ventilation for 48 hours or more
- Clinically stable with primary disease in remission
- Switched to assisted ventilation mode and planning to wean soon
You will not qualify if you...
- Severe neuromuscular diseases
- Central nervous system diseases
- Use of muscle relaxants for more than 48 hours
- Currently or soon to be discontinued from life support
- Contraindications to gastric tube insertion such as esophagogastric varices, digestive tract perforation, or recent upper digestive tract surgery
- Pregnant patients
- Poor ultrasound imaging window
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Minutes to hours during ventilator weaning
Participants are observed during mechanical ventilator weaning to assess blood phosphorus levels and neuro-excursion efficiency.
Assessments at 0, 1, 3, 5, 10, 20, and 30 minutes after initiation of the spontaneous breathing trial
Trial Site Locations
Total: 1 location
1
Peking Union Medical College Hospital
Beijing, China, 100730
Actively Recruiting
Research Team
S
Shitong Diao, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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