Study on How Low Blood Phosphorus Affects Breathing Muscle Function During Mechanical Ventilator Weaning in Adults

What this Trial Is About

Researchers are investigating the effects of low blood phosphate levels hypophosphatemia on patients undergoing mechanical ventilation in the intensive care unit ICU. This condition is common during ICU stays and has been linked to longer times on ventilators. The study aims to understand how hypophosphatemia affects diaphragm muscle function and nerve signals during the process of weaning patients off mechanical ventilation, with the goal of improving respiratory muscle strength and patient recovery. Patients eligible for the study have acute respiratory failure and have been on invasive ventilators for at least 48 hours. When patients meet criteria to begin weaning from the ventilator, they receive a diaphragm electromyography catheter to monitor muscle activity. They undergo a process called CPAP disconnection with measurements taken at multiple time points up to 30 minutes. Blood phosphate levels are monitored, and patients with low phosphate receive intravenous sodium glycerophosphate at doses adjusted to their phosphate level, while those with normal phosphate receive no special treatment. The procedure repeats 24 hours later to assess changes. Participants will be closely monitored with ventilator settings, diaphragm muscle activity, ultrasounds, and blood phosphate tests during the study. Researchers focus on measuring neural-excursion efficiency over time during the breathing trial. The study includes safety monitoring related to catheter placement and phosphate infusion. Participation involves multiple assessments during the weaning process and continues through a second evaluation after one day, helping researchers better understand phosphates role in respiratory muscle function during ventilator weaning.

Effect of Hypophosphatemia on Neuro-excursion Efficiency During Mechanical Ventilator Weaning