Actively Recruiting
Effect of Hypoxic Conditioning on Cerebrovascular Health in the Elderly
Led by University Hospital, Grenoble · Updated on 2026-05-08
64
Participants Needed
1
Research Sites
128 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how hypoxic conditioning, alone or combined with exercise training, affects cerebrovascular health in elderly people aged 60 to 80. This study aims to address age-related declines in vascular function that impact physical and cognitive abilities. Since some people cannot or do not want to do regular exercise, this research explores alternative ways to improve heart and brain health using controlled low-oxygen exposure. Participants will be randomly assigned to one of four groups: resting with intermittent hypoxia, resting with normal oxygen (placebo), exercising under hypoxia, or exercising with normal oxygen. Each group will undergo three sessions per week for eight weeks. The study will compare the effects of hypoxia at rest and during exercise to see which approach best supports cerebrovascular function. Throughout the study, researchers will measure middle cerebral artery blood flow velocity, peak oxygen uptake, blood vessel dilation, blood pressure, sleep quality, cognitive function, and health-related quality of life before the intervention, immediately afterwards, and two months later. The study includes four months of participation, combining the intervention period and follow-up assessments to monitor changes and safety.
CONDITIONS
Brief Title
Effect of Hypoxic Conditioning on Cerebrovascular Health in the Elderly
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 60 to 80 years of age
- Physically inactive, doing less than 150 minutes per week of moderate to intense physical activity
- No chronic cardiovascular, respiratory, metabolic, or neuromuscular diseases that prevent exercise or hypoxic conditioning
- Have health coverage
- Able to provide written informed consent
You will not qualify if you...
- Body mass index greater than 30 kg/m2
- Smoking cigarettes
- Alcohol use over 10 grams per day
- Mental disorder or history of mental disorder
- Taking beta-blocker medication
- Unable or unwilling to provide informed consent
- No health coverage
- Receiving allowances from other clinical trials exceeding annual limits
- Legally deprived of freedom by judicial or administrative decision
- Under legal protection and not eligible for clinical trials
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 weeks
Participants undergo sessions of hypoxic or normoxic conditioning at rest or during exercise to assess effects on cerebrovascular health.
3 sessions per week
Duration - 2 months
Participants are monitored to assess lasting effects of the intervention on cerebrovascular health and related outcomes.
1 visit (in-person) after intervention
Trial Site Locations
Total: 1 location
1
CHU Grenoble Alpes
La Tronche, Auvergne-Rhône-Alpes, France, 38700
Actively Recruiting
Research Team
S
Stéphane Doutreleau, MD, PhD
S
Samuel Vergès, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
4
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