Actively Recruiting

Phase 4
Age: 18Years +
All Genders
NCT07459049

"Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy"

Led by University of Baghdad · Updated on 2026-03-09

30

Participants Needed

1

Research Sites

34 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this ( Clinical Trial ) is to evaluate the efficacy of Ibuprofen in reducing acute inflammatory response (hs-CRP, ProCT, IL-6) after one hour and one week following one stage non surgical periodontal therapy. The main question it aims to answer is: "Does Ibuprofen effectively reduce the acute inflammatory response ( hs-CRP, ProCT, IL-6) following one-stage non-surgical periodontal therapy?"

CONDITIONS

Official Title

"Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy"

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Systemically healthy adults aged more than 18 years
  • Having at least 20 teeth
  • Diagnosed with generalized unstable periodontitis
  • Pocket depth of 4 mm or greater
  • Includes both smokers and non-smokers
Not Eligible

You will not qualify if you...

  • Allergy or hypersensitivity to Ibuprofen or other NSAIDs
  • Current use of systemic anti-inflammatory or antibiotic therapy within the last 3 months
  • History of peptic ulcer disease
  • Received periodontal therapy within the last 3 months
  • Asthma diagnosis
  • Renal impairment
  • Hepatic impairment
  • Severe cardiac disease including heart failure or hypertension
  • Bleeding disorders or use of anticoagulant medications
  • Known or suspected high risk for tuberculosis, hepatitis B, or HIV infections
  • Pregnant or lactating females
  • Unable to provide written informed consent

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

College of Dentistry, University of Baghdad

Baghdad, Iraq, 10047

Actively Recruiting

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Research Team

N

Nabaa Ismail Ibrahim, B.D.S

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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