Study of Ibuprofen to Reduce Inflammation After One-Stage Non-Surgical Periodontal Therapy in Adults with Periodontitis

What this Trial Is About

Researchers are evaluating the effect of Ibuprofen on reducing the acute inflammatory response after one-stage non-surgical periodontal therapy in adults with periodontitis. The study aims to answer whether Ibuprofen effectively lowers markers of inflammation such as hs-CRP, Procalcitonin, and IL-6 following this dental treatment. This is a randomized clinical trial focused on patients with generalized unstable periodontitis and a pocket depth of 4 mm or more. Participants will first attend a baseline visit where demographic information, clinical examination, and baseline blood samples will be collected. All will receive scaling and oral hygiene instructions, and one week later, clinical parameters will be recorded again. The test group will receive Ibuprofen doses starting one hour before root surface debridement and continuing three times daily for three days, while the control group will undergo the same dental procedure without Ibuprofen. Root surface debridement will be performed by a single periodontist, and treatment duration will be recorded. Participants will attend a follow-up visit one week after root surface debridement to collect blood samples, complete a pain questionnaire, and record plaque index to assess oral hygiene compliance. The main outcomes measured are changes in systemic inflammatory markers after seven days and postoperative pain using a visual analog scale. The study involves active monitoring of clinical parameters and patient-reported pain over the course of one week following treatment.

"Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy"