Evaluating Cough Assistance Techniques to Improve Breathing Support Removal in Critically Ill Adults

What this Trial Is About

This research aims to evaluate the impact of cough augmentation techniques on the success of weaning from mechanical ventilation in critically ill adult patients. These patients often have weakened cough strength due to factors such as mechanical ventilation, neuromuscular weakness, sedation, or respiratory muscle dysfunction, which can impair airway clearance and breathing support removal. The study compares two groups one receiving specialized cough augmentation techniques including manual assisted cough, lung volume recruitment maneuvers, and mechanical insufflation-exsufflation, and the other receiving routine care. Lung volume recruitment involves increasing end-inspiratory volume using pressure-controlled ventilation to improve cough effectiveness. These interventions are provided under physician supervision during the treatment period. Participants will be monitored to assess weaning success within 7 days. The study includes assessments of breathing function and airway clearance, with ongoing evaluation of patient responses. Researchers will track clinical outcomes related to breathing support removal, with safety and progress monitored throughout the study duration, which runs from July to November 2026.

Effect of Implementing Cough Augmentation Techniques on Weaning Outcomes Among Critically Ill Patients