Actively Recruiting
Effect of Injectable Hyaluronic Acid (HYADENT BG (HA)) on Bone Healing in Extraction Sockets
Led by Jordan University of Science and Technology · Updated on 2026-01-28
20
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Complications such as postoperative pain and delayed socket healing are relatively common following surgical extraction of mandibular third molars. Various biomaterials have been investigated to enhance wound healing and reduce postoperative morbidity. Hyaluronic acid (HA) has demonstrated anti-inflammatory and regenerative properties that may improve both soft and hard tissue healing. The aim of this study is to evaluate the effect of topical hyaluronic acid on postoperative pain and alveolar socket bone healing following surgical extraction of mandibular third molars. A prospective, randomized, controlled clinical trial with a split-mouth design will be conducted. Twenty patients requiring bilateral mandibular third molar surgical extraction will be enrolled. In each patient, one extraction socket will receive hyaluronic acid combined with a collagen sponge, while the contralateral socket will receive a collagen sponge alone, according to random allocation. Postoperative pain will be assessed using a visual analogue scale, and socket healing will be evaluated radiographically and histologically.
CONDITIONS
Official Title
Effect of Injectable Hyaluronic Acid (HYADENT BG (HA)) on Bone Healing in Extraction Sockets
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female participants aged 18 to 35 years
- Presence of bilateral impacted mandibular third molars classified as Pell and Gregory Class II, Position B
- Classified as American Society of Anesthesiologists (ASA) Physical Status I
- Absence of active local infection at the surgical site (e.g., no swelling, trismus, hyperthermia)
- Ability to maintain adequate oral hygiene
- Ability to understand and provide written informed consent
- Ability to read and understand Arabic or English
- Willingness to comply with study procedures and follow-up visits
You will not qualify if you...
- History of systemic diseases such as diabetes mellitus, hypertension, gastric ulcer, or other significant medical conditions
- Presence of severe or chronic illness requiring frequent hospitalization
- Pregnant or breastfeeding individuals
- History of cognitive or motor impairment that may interfere with study participation
- Use of anti-inflammatory or analgesic medications within two weeks before surgery
- Known allergy or hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs)
- Current smoker
- Use of anticoagulant therapy
- Any condition that, in the investigator's judgment, may interfere with healing or study outcomes
AI-Screening
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Trial Site Locations
Total: 1 location
1
Higher specialty training center
Irbid, Jordan, 11196
Actively Recruiting
Research Team
T
Tamimi
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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