Study of Injectable Hyaluronic Acid Gel to Improve Healing and Reduce Pain After Wisdom Tooth Surgery

What this Trial Is About

Researchers are studying the effects of topical hyaluronic acid on reducing pain and improving bone healing after the surgical removal of lower wisdom teeth. This clinical trial uses a split-mouth design, meaning each patient receives both treatments for comparison. The study will enroll 20 patients aged 18 to 35 years with specific types of impacted wisdom teeth, aiming to assess how hyaluronic acid combined with a collagen sponge affects recovery compared to collagen sponge alone. Each participant will undergo surgical extraction of both lower wisdom teeth performed by the same experienced surgeon. One extraction site will randomly receive hyaluronic acid gel with a collagen sponge, while the other site will receive only a collagen sponge. The procedure includes local anesthesia, bone removal if needed, and suturing, followed by standard postoperative care and suture removal after seven days. Pain will be recorded at 12 hours, day 3, and day 7 after surgery. Bone healing will be assessed through X-rays and tissue samples taken weeks after extraction. Participants will have their pain levels recorded using a visual scale and undergo radiographic imaging about eight weeks post-surgery to evaluate bone healing. Histological analysis of bone samples from both sockets will be done six weeks after the procedure to measure new bone formation. The study will analyze differences in pain and bone healing between the treated and control sites. The total study period includes surgery, follow-up visits, imaging, and tissue biopsy for detailed evaluation of healing.

Effect of Injectable Hyaluronic Acid (HYADENT BG (HA)) on Bone Healing in Extraction Sockets