Actively Recruiting
Led by Kutahya Health Sciences University · Updated on 2025-09-11
80
Participants Needed
1
Research Sites
17 weeks
Total Duration
Researchers are studying the effect of injectable platelet-rich fibrin on the soft tissue around dental implants in patients with insufficient peri-implant soft tissue. This study focuses on improving the keratinized mucosa width and mucosal thickness, which are important for implant health and appearance. Injectable platelet-rich fibrin, a bioactive agent rich in growth factors, has shown promise in supporting tissue regeneration around teeth, but its use around implants has not been previously explored. The study involves 80 systemically healthy, non-smoking patients over 18 years old who have limited peri-implant keratinized mucosa and mucosal thickness. Participants are divided into two groups based on their mucosa thickness: thin or thick phenotype. All patients receive the same procedure where injectable platelet-rich fibrin, prepared from their own blood, is applied subgingivally and submucosally around the implant sites. This treatment is repeated once a month for three months. Participants will undergo clinical evaluations including plaque and gingival indices, attachment loss, bleeding on probing, and measurements of keratinized mucosa and mucosal thickness. Standardized photographs and esthetic scoring will be performed before treatment and at 1, 3, 6, and 12 months after. The main outcomes measured are the width of keratinized mucosa and mucosal thickness around the implants over one year, along with esthetic improvements. This monitoring helps assess the potential benefits of the treatment on peri-implant soft tissue health and appearance.
CONDITIONS
The Effect of Injectable Platelet-Rich Fibrin in Peri-implant Soft Tissue
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 3 months
Participants receive injectable platelet-rich fibrin applied subgingivally and submucosally to the peri-implant soft tissue to improve tissue phenotype.
3 visits spaced 1 month apart
Duration - 12 months
Participants are monitored with standardized photographs and clinical assessments of peri-implant soft tissue phenotype over 12 months after treatment.
Visits at 1, 3, 6, and 12 months after treatment completion
Total: 1 location
1
Kütahya Health Sciences University Faculty of Dentistry
Kütahya, Turkey (Türkiye), 43100
Actively Recruiting
B
Berceste Güler Ayyıldız
S
Seyma Eken
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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